Early autism risk factors: a cohort study of children born very preterm at 5-years.

IF 2.3 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2026-08-12 DOI:10.1038/s41372-026-02856-x

Meg Stone-Heaberlin, Allison D Blackburn, Leanne Tamm, Armin Allahverdy, Beth Kline-Fath, Nehal A Parikh

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引用次数: 0

Abstract

Objective: Explore the association of prenatal, perinatal, and postnatal risk factors with autism risk at 5-years corrected age in very preterm (VPT) children.

Study design: Data from a longitudinal cohort study of 315 VPT and 172 term-born children at a US-based academic medical center were analyzed, exploring antecedents of autism risk using elastic net regression.

Results: More children born VPT (8.9%) had a Social Communication Questionnaire score associated with autism (i.e., SCQ ≥ 15) than term-born controls (2.9%; p = 0.012). For VPT children, cerebellar abnormalities at term-equivalent age (OR = 1.339, 95% CI = 1.010-1.778) and moderate-severe histologic chorioamnionitis (OR = 4.148, CI = 1.294-13.368) were significantly associated with autism risk, in addition to male sex and social risk. VPT children with SCQ ≥ 15 had poorer adaptive, behavioral, cognitive, and executive functioning (all ps < 0.001).

Conclusion: Early screening for children with these risk factors can facilitate early intervention for those at most risk for poorer neurodevelopmental outcomes.

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早期自闭症风险因素：一项针对5岁早产儿的队列研究。

目的：探讨极早产儿（VPT） 5岁时产前、围产期和产后危险因素与自闭症风险的关系。研究设计：对美国某学术医疗中心315名早产儿和172名足月新生儿的纵向队列研究数据进行分析，利用弹性净回归法探索自闭症风险的前因变量。结果：与足月出生的对照组（2.9%,p = 0.012）相比，VPT出生的儿童（8.9%）有更多的社会沟通问卷得分与自闭症相关（即SCQ≥15）。对于VPT患儿，除了男性和社会风险外，足月等龄小脑异常（OR = 1.339, 95% CI = 1.010-1.778）和中重度组织学绒毛膜羊膜炎（OR = 4.148, CI = 1.294-13.368）与自闭症风险显著相关。SCQ≥15的VPT儿童的适应、行为、认知和执行功能较差。结论：对具有这些危险因素的儿童进行早期筛查，可以促进对那些神经发育预后较差的高危儿童进行早期干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.