Acinetobacter bereziniae co-producing NDM-1 and OXA-58 causing pneumonia and stomatitis in a Burmese python (Python bivittatus)

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

Journal of global antimicrobial resistance Pub Date : 2026-09-01 Epub Date: 2026-08-12 DOI:10.1016/j.jgar.2026.08.008

Gabriel Siqueira dos Santos, Julia de Menezes Macedo Pausa, Caroline da Costa Abrahão, Alice Soares de Oliveira, João Pessoa Araújo Junior, Amanda Haisi, Luciana Sartori, José Soares Ferreira Neto, Marcos Bryan Heinemann

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引用次数: 0

Abstract

Carbapenemase-producing Acinetobacter are multidrug-resistant pathogens mainly associated with healthcare infections but are increasingly detected in wildlife exposed to human environments. In this study, we report and characterize a carbapenem-resistant Acinetobacter bereziniae strain related to fatal pneumonia and stomatitis in a rescued Burmese python (Python bivittatus) in São Paulo, Brazil. Whole genome sequencing revealed plasmid-borne bla_NDM-1 and bla_OXA-58 genes, and phylogenomic analysis clustered the strain with human clinical isolates. These findings highlight the threat of carbapenemase-producing bacteria to wildlife and reinforce the need for a One Health surveillance approach.

查看原文本刊更多论文

联合产生NDM-1和OXA-58的不动杆菌在缅甸蟒蛇（python bivittatus）中引起肺炎和口炎。

产碳青霉烯酶不动杆菌（CPA）是一种多药耐药病原体，主要与卫生保健感染有关，但越来越多地在暴露于人类环境的野生动物中被发现。在这项研究中，我们报告并描述了一种碳青霉烯耐药不动杆菌bereziniae菌株，该菌株与巴西圣保罗获救的缅甸蟒蛇（python bivittatus）的致命性肺炎和口炎有关。全基因组测序显示质粒携带blaNDM-1和blaOXA-58基因，系统基因组分析与人类临床分离株聚类。这些发现强调了产生碳青霉烯酶的细菌对野生动物的威胁，并加强了“同一个健康”监测方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

8.70

自引率

2.20%

发文量

285

审稿时长

34 weeks

期刊介绍： The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.