Christina K Tripsas, Abigail Y Tsai, Jeffrey J Hsu
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引用次数: 0
Abstract
Purpose of review: Endothelial-to-mesenchymal transition (EndMT) has been implicated in the development of cardiovascular disease, including atherosclerosis. EndMT is a complex continuum with multiple involved pathways, each with different pathophysiologic implications depending on the driving regulators.
Recent findings: In this brief review, we will focus on the latest studies that have helped elucidate the role of lipids and related factors in the initiation of EndMT in the setting of atherosclerosis, with particular attention to atherosclerotic plaque stability and sex specific differences of disease.
Summary: We explore potential therapeutic strategies, including the impact that lipid modulation has on EndMT and the effects of EndMT-specific approaches on lipid deposition. Overall, this will inform future areas of research on EndMT modulation.
期刊介绍：
With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
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