{"title":"Functional gonadotroph adenomas.","authors":"Diane Donegan, Dana Erickson","doi":"10.1097/MED.0000000000000973","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Functional gonadotroph tumors (FGTs) are rare tumors of the anterior pituitary gland which produce and secrete gonadotropins leading to symptoms. Given that these tumors are not common, there is limited information available regarding optimal management.</p><p><strong>Recent findings: </strong>Symptoms attributable to gonadotropin secretion are often nonspecific in men and is often underrecognized in women. Consequently, many patients present with symptoms related to tumor mass effect, including visual changes and/or headaches, and are subsequently - or retrospectively - recognized to have an FGT.</p><p><strong>Summary: </strong>A high level of clinical suspicion and thorough investigations will allow for detection of FGT. Like other pituitary tumors, surgery is the primary form of treatment. Although long-term follow-up data are limited given the rarity of this tumor, recurrence is reported and therefore long-term follow-up is necessary.</p>","PeriodicalId":10964,"journal":{"name":"Current Opinion in Endocrinology & Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Endocrinology & Diabetes and Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MED.0000000000000973","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Functional gonadotroph tumors (FGTs) are rare tumors of the anterior pituitary gland which produce and secrete gonadotropins leading to symptoms. Given that these tumors are not common, there is limited information available regarding optimal management.
Recent findings: Symptoms attributable to gonadotropin secretion are often nonspecific in men and is often underrecognized in women. Consequently, many patients present with symptoms related to tumor mass effect, including visual changes and/or headaches, and are subsequently - or retrospectively - recognized to have an FGT.
Summary: A high level of clinical suspicion and thorough investigations will allow for detection of FGT. Like other pituitary tumors, surgery is the primary form of treatment. Although long-term follow-up data are limited given the rarity of this tumor, recurrence is reported and therefore long-term follow-up is necessary.
期刊介绍：
Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.
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