A Comparative Analysis of Virtual 2D VMAT-Based SFRT and 3D Lattice Radiotherapy: Evaluation of Dosimetric and Therapeutic Outcomes.

Q3 Medicine

Journal of Biomedical Physics and Engineering Pub Date : 2026-08-01 DOI:10.31661/jbpe.v0i0.2410-1835

Elnaz Balvasi, Farshid Mahmoudi, Parastoo Farina, Ali Ameri, Fatemeh Jafari, Ghazale Geraily

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引用次数: 0

Abstract

Background: Spatially Fractionated Radiotherapy (SFRT) can be implemented using Volumetric-Modulated Arc Therapy (VMAT) in either two-dimensional (2D) or three-dimensional (3D) configurations.

Objective: This study aimed to compare the dosimetric and clinical outcomes of two VMAT-based SFRT techniques for large lung tumors.

Material and methods: In this experimental study, SFRT plans were designed for each patient using cylindrical and spherical grid targets. Single-fraction prescription doses of 15 and 20 Gy were delivered to the grid target isocenters using 6 MV Flattening-filter-free (FFF) photon beams.

Results: The 2D SFRT plan demonstrated higher Gross Tumor Volume (GTV) mean dose, GTV Equivalent Uniform Dose (EUD), and Valley-to-peak Dose ratio (VPDR) compared to the 3D lattice plan. However, the 3D Lattice Radiotherapy (3D-LRT) technique provided a better therapeutic ratio and more uniform valley-peak dose distribution. Both plans demonstrated therapeutic ratios greater than one with minimal Normal Tissue Complication Probability (NTCP).

Conclusion: Both 2D and 3D lattice VMAT-based SFRT techniques effectively delivered high radiation doses with steep dose gradients within the GTV, minimizing normal tissue exposure and reducing the risk of complications.

查看原文本刊更多论文

基于虚拟二维vmat的SFRT和三维点阵放疗的比较分析：剂量学和治疗结果的评估。

背景：空间分割放疗（SFRT）可以在二维（2D）或三维（3D）配置中使用体积调制电弧治疗（VMAT）来实现。目的：本研究旨在比较两种基于vmat的SFRT技术治疗大肺肿瘤的剂量学和临床结果。材料与方法：在本实验研究中，采用圆柱形和球形网格靶为每位患者设计了SFRT计划。使用6 MV无平坦滤波（FFF）光子束将15和20 Gy的单组分处方剂量传递到网格目标等中心。结果：与三维点阵方案相比，二维SFRT方案显示出更高的总肿瘤体积（GTV）平均剂量、GTV等效均匀剂量（EUD）和谷峰剂量比（VPDR）。而三维点阵放疗（3D- lrt）技术具有更好的治疗比和更均匀的谷峰剂量分布。两种方案的治疗率均大于正常组织并发症概率（NTCP）最小的方案。结论：基于二维和三维点阵vmat的SFRT技术均能有效地在GTV内提供高剂量和陡剂量梯度的辐射，最大限度地减少正常组织暴露，降低并发症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.