Effect of oral probiotics on postoperative nutrition level of patients with liver cancer.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2026-08-12 eCollection Date: 2026-01-01 DOI:10.1515/med-2026-1485

Xiaohan Wang, Ziming Wang

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引用次数: 0

Abstract

Objectives: To determine the effect of probiotics on the postoperative nutritional status of patients with liver cancer.

Methods: A total of 112 patients with liver cancer were enrolled from January 2021 to December 2022 and randomly assigned to either a probiotics group (n=56) or a placebo group (n=56). Patients in the probiotics group received oral administration of either bifid-triple viable capsules (420 mg, three times daily) or Bacillus subtilis capsules (0.5 g, three times daily) for 21 consecutive days. Patients in the placebo group received identical-looking placebo capsules following the same schedule. All patients received routine nursing care and nutritional support during hospitalization. Nutritional status was assessed at baseline (day 0) and at 7, 14, and 21 days after intervention using the patient-generated subjective global assessment (PG-SGA) score, serum levels of albumin (Alb), prealbumin (PA), hemoglobin (Hb) and transferrin (TRF), as well as arm muscle circumference (AMC) and triceps skinfold thickness (TSF) measurements.

Results: After 21 d, PG-SGA score was obviously reduced in probiotics group and placebo group relative to 0 d (p<0.05). Moreover, the decrease of PG-SGA score was more in probiotics group than placebo group (p<0.05). After 21 d, the increased levels of Alb, PA, Hb and TRF in serums were more in probiotics group than placebo group (p<0.05). Furthermore, the increases of AMC value and TSF value were more in probiotics group than placebo group after 21 d (p<0.05).

Conclusions: Oral probiotics had a good feedback on improving postoperative nutrition level in patients with liver cancer.

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口服益生菌对肝癌患者术后营养水平的影响。

目的：探讨益生菌对肝癌术后患者营养状况的影响。方法：从2021年1月至2022年12月，共有112例肝癌患者入组，随机分为益生菌组（n=56）和安慰剂组（n=56）。益生菌组患者口服双歧三联活菌胶囊（420 mg，每日3次）或枯草芽孢杆菌胶囊（0.5 g，每日3次），连续21天。安慰剂组的患者按照相同的时间表接受外观相同的安慰剂胶囊。所有患者在住院期间均接受常规护理和营养支持。在基线（第0天）和干预后第7、14和21 天，使用患者主观总体评估（PG-SGA）评分、血清白蛋白（Alb）、白蛋白前（PA）、血红蛋白（Hb）和转铁蛋白（TRF）水平，以及手臂肌肉周长（AMC）和三头肌皮襞厚度（TSF）测量来评估营养状况。结果：21 d后，益生菌组和安慰剂组PG-SGA评分较0 d明显降低（p0.05）。此外，益生菌组PG-SGA评分的下降幅度大于安慰剂组（p0.05）。21 d后，益生菌组血清中Alb、PA、Hb和TRF水平的升高高于安慰剂组（p0.05）。在21 d后，益生菌组的AMC值和TSF值的升高高于安慰剂组（p0.05）。结论：口服益生菌对改善肝癌患者术后营养水平有较好的反馈作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.