{"title":"Metal-based putty implant functionalized with copper nanoparticles for bone tissue regeneration.","authors":"Rethinam Senthil, Pelluru Geetha Sravanthy","doi":"10.1177/03913988261473524","DOIUrl":null,"url":null,"abstract":"<p><p>This study developed and evaluated a sodium alginate/hydroxyapatite/copper nanoparticle (SA/HA/CuNPs) putty implant for bone tissue engineering. The green-synthesized CuNPs product was characterized by UV-Vis, FTIR, XRD, and FESEM analyses. The putty implant exhibited a porous structure, enhanced biomineralization, antioxidant activity, and strong antibacterial effects against gram-positive (22.4 ± 1.2 mm) and gram-negative (19.8 ± 1.0 mm) bacteria. Mechanical testing showed tensile and compressive strengths of 8.6 ± 0.5 MPa and 14.2 ± 0.8 MPa, respectively. Cytocompatibility studies demonstrated >86% cell viability and favorable live/dead staining results. Overall, the SA/HA/CuNP implant showed promising potential for bone regeneration applications.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261473524"},"PeriodicalIF":1.6000,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Artificial Organs","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/03913988261473524","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This study developed and evaluated a sodium alginate/hydroxyapatite/copper nanoparticle (SA/HA/CuNPs) putty implant for bone tissue engineering. The green-synthesized CuNPs product was characterized by UV-Vis, FTIR, XRD, and FESEM analyses. The putty implant exhibited a porous structure, enhanced biomineralization, antioxidant activity, and strong antibacterial effects against gram-positive (22.4 ± 1.2 mm) and gram-negative (19.8 ± 1.0 mm) bacteria. Mechanical testing showed tensile and compressive strengths of 8.6 ± 0.5 MPa and 14.2 ± 0.8 MPa, respectively. Cytocompatibility studies demonstrated >86% cell viability and favorable live/dead staining results. Overall, the SA/HA/CuNP implant showed promising potential for bone regeneration applications.
期刊介绍：
The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.
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