The Burden of Chronic Spontaneous Urticaria: A Narrative Literature Review.

IF 3.6 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2026-08-11 DOI:10.1159/000553409

Chien-Chia Chuang, Jennifer Boss, Ryan B Thomas

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引用次数: 0

Abstract

Background: Chronic spontaneous urticaria (CSU) accounts for most cases of chronic urticaria; however, the prevalence and disease burden are not well characterized.

Summary: A narrative literature review based on structured and targeted searches of the literature and iterative hand searches based on expert knowledge was conducted to assess the epidemiology and humanistic burden of CSU. Targeted searches were conducted in EMBASE (including conference abstracts), MEDLINE, and health technology agencies using a combination of terms related to "chronic spontaneous urticaria" between January 1, 2010, and June 13, 2023.

Key messages: The searches retrieved a total of 62 articles. CSU prevalence was reported at 0.08%-2% across Asia, Europe/UK, North America, and South America. Risk factors reported for CSU included female sex, older age, and autoimmune conditions. Itch was the primary and most troublesome symptom. CSU has a significant burden on physical and mental health-related quality of life (HRQoL). Healthcare resource utilization (HCRU) in patients with CSU was driven by outpatient physician office and emergency department visits. Poorly controlled CSU led to greater impact on HRQoL and HCRU. In total, 24 articles reported on available treatment approaches and/or emerging therapies that target the underlying pathophysiology of CSU. Significant evidence gaps were identified, including the need for epidemiological data from a wider range of geographic regions and economic and cost-of-illness analyses. This narrative literature review demonstrates that CSU is associated with a significant burden of symptoms, reduced HRQoL, and HCRU. Early and appropriate diagnosis and new, effective treatment options are needed for patients with CSU.

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慢性自发性荨麻疹的负担：叙述性文献综述。

背景：慢性自发性荨麻疹（CSU）占慢性荨麻疹病例的大多数；然而，患病率和疾病负担并没有很好地表征。摘要：采用结构化、针对性的文献检索和基于专家知识的迭代手检索的叙事性文献综述，对CSU的流行病学和人文负担进行评估。在2010年1月1日至2023年6月13日期间，在EMBASE（包括会议摘要）、MEDLINE和卫生技术机构中使用与“慢性自发性荨麻疹”相关的术语组合进行目标搜索。关键信息：这些搜索总共检索到62篇文章。据报道，亚洲、欧洲/英国、北美和南美的CSU患病率为0.08%-2%。据报道，CSU的危险因素包括女性、年龄较大和自身免疫性疾病。瘙痒是最主要和最麻烦的症状。CSU对身心健康相关生活质量（HRQoL）造成了重大负担。CSU患者的医疗资源利用率（HCRU）受门诊医师办公室和急诊科访问量的影响。CSU控制不佳对HRQoL和HCRU的影响较大。24篇文章报道了针对CSU潜在病理生理的现有治疗方法和/或新兴疗法。确定了重大的证据差距，包括需要来自更广泛地理区域的流行病学数据以及经济和疾病成本分析。本叙述性文献综述表明，CSU与显著的症状负担、HRQoL降低和HCRU相关。CSU患者需要早期、适当的诊断和新的、有效的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.