A new phase in KRAS signaling.

IF 21.6 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2026-10-01 Epub Date: 2026-08-11 DOI:10.1016/j.trecan.2026.07.007

Krista A Budinich, Liling Wan

引用次数: 0

Abstract

By positioning phase separation between Kirsten rat sarcoma virus oncogene homolog (KRAS) lipidation and membrane signaling, Wang et al. unify distinct aspects of KRAS biology. They show that farnesylation drives cytoplasmic KRAS condensates that promote processing, trafficking, and signaling, establishing condensat formation as a new mechanism for controlling RAS activity.

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KRAS信号传导的新阶段。

Wang等人通过Kirsten大鼠肉瘤病毒癌基因同源物（KRAS）脂化和膜信号传导之间的相分离定位，统一了KRAS生物学的不同方面。他们表明，法尼化驱动细胞质KRAS凝聚物，促进加工、运输和信号传导，建立凝聚物形成作为控制RAS活性的新机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.