The proteome comes of age, but precision oncology needs functional maps

IF 94.6 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2026-08-10 DOI:10.1038/s41571-026-01196-1

Emanuel Petricoin, Thomas Conrads, Lance Liotta

引用次数: 0

Abstract

Yue and colleagues present a landmark anatomical atlas of human protein abundance across non-malignant tissues and cancers. We argue that precision oncology needs functional proteomic maps that add signalling activity, post-translational modifications, pathology-guided compartment resolution, metastatic and longitudinal sampling, clinical annotation and population diversity to make proteomics therapeutically actionable.

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蛋白质组学已经成熟，但精确的肿瘤学需要功能图谱。

Yue和他的同事们展示了人类非恶性组织和癌症中蛋白质丰度的里程碑式解剖图谱。我们认为，精确肿瘤学需要功能性蛋白质组学图，这些图可以增加信号活性、翻译后修饰、病理引导的室分辨率、转移性和纵向采样、临床注释和群体多样性，从而使蛋白质组学具有治疗可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.