Reproductive, lifestyle, socioeconomic and anthropometric correlates of early menopause.

IF 3.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2026-08-11 DOI:10.1080/13697137.2026.2707856

Keiko Yamanouchi, Tsuyoshi Ohta, Tsuneo Konta, Risako Yamaguchi, Midori Saito, Fumihiro Nakamura, Shouta Horikawa, Kazuyoshi Sakai, Norikazu Watanabe, Manabu Seino, Satoru Nagase

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引用次数: 0

Abstract

Objective: This study aimed to identify lifestyle, reproductive and socioeconomic correlates of early menopause (age <45 years) in a cross-sectional analysis of a population-based cohort of Japanese women.

Method: The study analyzed data from 6313 naturally menopausal women in the Yamagata Cohort Study (2009-2015). Women were classified as having early menopause (age <45 years; n = 239) or menopause at age 45-54 years (n = 6074). Data included age at menarche, menstrual pattern at age 20 years, educational attainment, marital status, parity, breastfeeding, smoking and body mass index (BMI). Multivariable logistic regression estimated odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Lower educational attainment (OR 1.84, 95% CI 1.32-2.57) and never-married status (OR 2.52, 95% CI 1.24-5.11) were associated with early menopause. Low BMI was associated with early menopause in univariate analysis but not after multivariable adjustment. An interaction was observed between menstrual pattern at age 20 years and BMI: among women with menstrual irregularity, obesity (BMI ≥25 kg/m²) was associated with higher odds of early menopause (OR 3.49, 95% CI 1.91-6.37).

Conclusion: In this cross-sectional analysis of a population-based cohort of Japanese women, lower educational attainment and never-married status were associated with early menopause. Women with menstrual irregularity and obesity may be at increased risk of early menopause.

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生殖、生活方式、社会经济和人体测量学与早期绝经相关。

目的：本研究旨在确定早期绝经（年龄）的生活方式、生殖和社会经济相关因素。方法：本研究分析了Yamagata队列研究（2009-2015）中6313名自然绝经妇女的数据。女性被分为早期绝经（n = 239）和45-54岁绝经（n = 6074）。数据包括初潮年龄、20岁时的月经模式、受教育程度、婚姻状况、胎次、母乳喂养、吸烟和体重指数（BMI）。多变量logistic回归以95%置信区间（ci）估计优势比（ORs）。结果：较低的受教育程度（OR 1.84, 95% CI 1.32-2.57）和未婚状态（OR 2.52, 95% CI 1.24-5.11）与早期绝经有关。在单变量分析中，低BMI与早期绝经相关，但在多变量调整后则无相关。20岁时的月经模式与BMI之间存在相互作用：在月经不规律的女性中，肥胖（BMI≥25 kg/m2）与早期绝经的几率较高相关（OR 3.49, 95% CI 1.91-6.37）。结论：在对日本女性人群的横断面分析中，低教育程度和未婚状态与早期绝经有关。月经不规律和肥胖的女性提前绝经的风险可能会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.