Ali Ghanem Al Masad, Mahdi Abdulhadi Al Muammar, Omar Reda Abdelmaksoud
{"title":"Severe Chronic Anemia and Tumor-Mimicking Colonic Lesions as an Atypical Presentation of Crohn's Colitis.","authors":"Ali Ghanem Al Masad, Mahdi Abdulhadi Al Muammar, Omar Reda Abdelmaksoud","doi":"10.14309/crj.0000000000002258","DOIUrl":null,"url":null,"abstract":"<p><p>Crohn's colitis may rarely present with severe bleeding and tumor-mimicking colonic lesions, creating concern for malignancy. A 20-year-old bedridden man with cerebral palsy had recurrent hematochezia and transfusion-dependent microcytic anemia, with hemoglobin 2.8 g/dL. Colonoscopy showed diffuse raised island-like plaques with vascular-pattern loss, rectal sparing, edematous ileocecal valve, and an oozing transverse-colon lesion requiring clipping. Multisite biopsies showed chronic active colitis with crypt distortion, cryptitis, and crypt abscesses, without granulomas, dysplasia, or malignancy. Tissue tuberculosis polymerase chain reaction was negative; interferon-gamma release assay was unavailable. Crohn's colitis was favored by clinicopathologic correlation. Bleeding resolved after corticosteroids, infliximab, and azathioprine; hemoglobin improved to 9.9 g/dL.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02258"},"PeriodicalIF":0.6000,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456836/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACG Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/crj.0000000000002258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Crohn's colitis may rarely present with severe bleeding and tumor-mimicking colonic lesions, creating concern for malignancy. A 20-year-old bedridden man with cerebral palsy had recurrent hematochezia and transfusion-dependent microcytic anemia, with hemoglobin 2.8 g/dL. Colonoscopy showed diffuse raised island-like plaques with vascular-pattern loss, rectal sparing, edematous ileocecal valve, and an oozing transverse-colon lesion requiring clipping. Multisite biopsies showed chronic active colitis with crypt distortion, cryptitis, and crypt abscesses, without granulomas, dysplasia, or malignancy. Tissue tuberculosis polymerase chain reaction was negative; interferon-gamma release assay was unavailable. Crohn's colitis was favored by clinicopathologic correlation. Bleeding resolved after corticosteroids, infliximab, and azathioprine; hemoglobin improved to 9.9 g/dL.
期刊介绍:
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.