Severe Chronic Anemia and Tumor-Mimicking Colonic Lesions as an Atypical Presentation of Crohn's Colitis.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY
ACG Case Reports Journal Pub Date : 2026-08-10 eCollection Date: 2026-08-01 DOI:10.14309/crj.0000000000002258
Ali Ghanem Al Masad, Mahdi Abdulhadi Al Muammar, Omar Reda Abdelmaksoud
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引用次数: 0

Abstract

Crohn's colitis may rarely present with severe bleeding and tumor-mimicking colonic lesions, creating concern for malignancy. A 20-year-old bedridden man with cerebral palsy had recurrent hematochezia and transfusion-dependent microcytic anemia, with hemoglobin 2.8 g/dL. Colonoscopy showed diffuse raised island-like plaques with vascular-pattern loss, rectal sparing, edematous ileocecal valve, and an oozing transverse-colon lesion requiring clipping. Multisite biopsies showed chronic active colitis with crypt distortion, cryptitis, and crypt abscesses, without granulomas, dysplasia, or malignancy. Tissue tuberculosis polymerase chain reaction was negative; interferon-gamma release assay was unavailable. Crohn's colitis was favored by clinicopathologic correlation. Bleeding resolved after corticosteroids, infliximab, and azathioprine; hemoglobin improved to 9.9 g/dL.

重度慢性贫血和肿瘤样结肠病变是克罗恩结肠炎的非典型表现。
克罗恩结肠炎可能很少出现严重出血和类似肿瘤的结肠病变,引起对恶性肿瘤的关注。20岁卧床不起的脑瘫男性,复发性便血和输血依赖性小细胞性贫血,血红蛋白2.8 g/dL。结肠镜检查显示弥漫性升高的岛状斑块伴血管模式丧失,直肠保留,回盲瓣水肿,需要夹闭的横向结肠病变。多部位活检显示慢性活动性结肠炎伴隐窝扭曲、隐窝炎和隐窝脓肿,无肉芽肿、发育不良或恶性肿瘤。组织结核聚合酶链反应阴性;没有干扰素释放试验。克罗恩结肠炎有临床病理相关性。皮质类固醇、英夫利昔单抗和硫唑嘌呤治疗后出血消失;血红蛋白改善至9.9 g/dL。
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来源期刊
ACG Case Reports Journal
ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-
自引率
14.30%
发文量
170
审稿时长
12 weeks
期刊介绍: ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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