Fatigue in Parkinson's Disease: A Cross-Sectional Study of Prevalence and Clinical Correlates.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2026-09-01 Epub Date: 2026-08-04 DOI:10.4103/aian.aian_117_26

Pramod Khanda, Vikram V Holla, Nitish Kamble, Ravi Yadav, Pramod Pal, Rohan R Mahale

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引用次数: 0

Abstract

Background and objectives: Fatigue is a non-motor symptoms (NMS) of Parkinson's disease (PD). The study aimed to determine the frequency and severity of fatigue, its predictors, and its impact on quality of life.

Methods: We included 150 patients with PD. The Fatigue Severity Scale (FSS) and the Parkinson Fatigue Scale-16 (PFS-16) were used to assess the presence and severity of fatigue.

Results: The frequency of fatigue was 46%, predominantly of mild severity. The mean FSS score was 33.3 ± 10.3. Patients with fatigue were older, had a longer disease duration, received higher levodopa doses, and had greater motor and NMS severity. Anxiety and depression scores were higher, along with a greater frequency of excessive daytime sleepiness and sleep disturbances. Fatigue had a negative impact on quality of life. Multivariate analysis identified disease duration, motor severity, and depression as independent predictors of fatigue.

Conclusions: Fatigue is a frequent yet underrecognized NMS in PD. Nearly half of the patients experienced fatigue, mostly of mild severity, and it was associated with longer disease duration, greater disease severity, mood disturbances, sleep-related symptoms, and reduced quality of life.

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帕金森病的疲劳：患病率和临床相关因素的横断面研究

背景与目的：疲劳是帕金森病（PD）的一种非运动症状（NMS）。该研究旨在确定疲劳的频率和严重程度、预测因素及其对生活质量的影响。方法：纳入150例PD患者。采用疲劳严重程度量表（FSS）和帕金森疲劳量表-16 （PFS-16）评估疲劳的存在和严重程度。结果：疲劳发生率为46%，以轻度为主。FSS平均评分为33.3±10.3分。疲劳患者年龄较大，病程较长，左旋多巴剂量较高，运动和NMS严重程度较高。焦虑和抑郁得分更高，白天过度嗜睡和睡眠障碍的频率也更高。疲劳对生活质量有负面影响。多变量分析确定疾病持续时间、运动严重程度和抑郁是疲劳的独立预测因素。结论：疲劳是PD患者常见但未被充分认识的NMS。近一半的患者感到疲劳，大多数是轻微的严重程度，并且与疾病持续时间更长、疾病严重程度更高、情绪障碍、睡眠相关症状和生活质量下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.