Epidemiological and clinical insights from Type 1 Diabetes Global Registries: A systematic review and meta-analysis

IF 4.4 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2026-07-01 Epub Date: 2026-07-23 DOI:10.1016/j.dsx.2026.103455

Rupali Chauhan, Riddhi Solanki, Mahira Saiyed, Banshi Saboo, Komal Shah

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引用次数: 0

Abstract

Background

Type 1 diabetes (T1D) incidence is rising globally, especially among children, with Systematic evaluation of these registries can highlight disparities in diagnosis, access, and management while supporting cross-regional learning to improve care delivery.

Objective

To assess the global burden of T1D by synthesizing key epidemiological indicators, including incidence, complications, and management approaches in children aged 0-14 years, and to characterize registry populations by sociodemographic and clinical features to identify care disparities.

Methods

A systematic review and meta-analysis of five databases identified 51 eligible studies (1969–2023). Data on incidence, diabetic ketoacidosis (DKA), and continuous glucose monitoring (CGM) use were pooled from 39 studies.

Results

51 studies comprising 433,727 participants from 38 countries were analysed. Registries included 20 national, 11 regional, and 7 hospital-based datasets. The pooled global incidence of T1D was 20.16 per 100,000 population (95% CI: 16.49–23.84; I² = 89%). Incidence varied geographically, with higher estimates reported in Europe (22.2/100,000) compared with Asia (8.90/100,000). Registries applying ISPAD criteria reported higher incidence estimates (26.45/100,000) compared with EURODIAB criteria (19.15/100,000), although diagnostic criteria subgroup differences were not statistically significant. No significant gender differences were observed. DKA at diagnosis occurred in 38% of children, with substantial variability across settings. CGM use was reported in only four registries, with a pooled prevalence of 12.5%, highlighting gaps in access and adoption of diabetes technologies.

Conclusion

Global T1D registries demonstrate substantial heterogeneity in incidence and persistent disparities in diagnosis and diabetes care. Harmonized registry standards and equitable access to diabetes technologies are needed to strengthen surveillance and improve outcomes.

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来自1型糖尿病全球登记的流行病学和临床见解：系统回顾和荟萃分析。

背景：1型糖尿病（T1D）的发病率正在全球范围内上升，尤其是在儿童中，对这些登记进行系统评估可以突出诊断、获取和管理方面的差异，同时支持跨区域学习以改善护理提供。目的：通过综合主要流行病学指标，包括0-14岁儿童T1D的发病率、并发症和管理方法，评估全球T1D负担，并通过社会人口学和临床特征对登记人群进行表征，以确定护理差异。方法：对5个数据库进行系统回顾和荟萃分析，确定了51项符合条件的研究（1969-2023）。发病率、糖尿病酮症酸中毒（DKA）和连续血糖监测（CGM）使用的数据来自39项研究。结果：分析了51项研究，包括来自38个国家的433,727名参与者。登记处包括20个国家、11个地区和7个医院数据集。T1D的全球总发病率为20.16 / 10万人（95% CI: 16.49-23.84; I2 = 89%）。发病率因地域而异，欧洲报告的发病率（22.2/10万）高于亚洲（8.90/10万）。应用ISPAD标准的注册中心报告的发病率估计值（26.45/100,000）高于EURODIAB标准（19.15/100,000），尽管诊断标准亚组差异无统计学意义。没有观察到显著的性别差异。诊断时DKA发生在38%的儿童中，在不同的环境中有很大的差异。只有4个登记中心报告了CGM的使用情况，总流行率为12.5%，突出了糖尿病技术获取和采用方面的差距。结论：全球T1D登记显示在发病率和诊断和糖尿病护理方面持续存在差异。需要统一登记标准和公平获得糖尿病技术，以加强监测和改善结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.