Incidence of Acute Cystoid Macular Edema After Penetrating Keratoplasty and Endothelial Keratoplasty.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2026-09-01 Epub Date: 2026-08-08 DOI:10.1055/a-2932-7648

Ibrahim Qozat, Yazan Abubaker, Pranav Vasu, Isabella Wagner, Conner Lentz, Emily Dorairaj, Abhimanyu Ahuja, Darby Miller, Michael Stewart, Syril Dorairaj

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引用次数: 0

Abstract

Abstract: INTRODUCTION: Cystoid macular edema (CME) is a recognized complication associated with penetrating keratoplasty (PK) and Endothelial Keratoplasty (EK). The purpose of this study was to determine the incidence of acute CME within the first 6 months after PK, Descemet stripping automated EK, or Descemet's membrane EK.

Abstract: METHODS: A retrospective cohort analysis of the TriNetX United States collaborative database was conducted. Patients with a diagnosis of Fuchs dystrophy or keratoconus who underwent PK or EK between January 1, 2004 and August 30, 2024 were included. Those with a history of uveitis, retinal vascular occlusion, diabetic macular edema, or prior vitrectomy were excluded. Outcomes and diagnoses were defined using current procedural terminology and International Classification of Diseases, Tenth edition (ICD-10) codes. Cohorts were stratified based on a history of prior PK or EK with >6 months follow-up. Propensity score matching was performed on both cohorts to control for age at index, sex, race, ethnicity, and the diagnosis of Fuchs dystrophy and keratoconus. The incidence of acute CME during a 6-month postoperative follow-up period was assessed. Odds ratios were calculated between cohorts.

Abstract: RESULTS: A total of 2516 eyes were included in the study (PK: 1258; EK: 1258). At six months postoperatively, the incidence of acute CME in the EK cohort (46 of 1258) was significantly higher than in the PK cohort (20 of 1258) (P = 0.0012) (OR 0.426, 95% confidence interval 0.25-0.72).

Abstract: CONCLUSIONS: Our findings suggest that the incidence of acute CME is higher in patients undergoing EK compared to PK.

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[穿孔角膜成形术和内皮角膜成形术后急性囊性黄斑水肿的发病率]。

摘要：囊样黄斑水肿（CME）是一种公认的与穿透性角膜移植术（PK）和内皮性角膜移植术（EK）相关的并发症。本研究的目的是确定在PK、Descemet剥离自动EK或Descemet膜EK后的前6个月内急性CME的发生率。摘要：方法：对TriNetX美国合作数据库进行回顾性队列分析。在2004年1月1日至2024年8月30日期间接受PK或EK的诊断为Fuchs营养不良或圆锥角膜的患者纳入研究。排除有葡萄膜炎、视网膜血管闭塞、糖尿病性黄斑水肿或既往玻璃体切除史的患者。使用现行程序术语和《国际疾病分类》第十版（ICD-10）代码定义结果和诊断。根据既往PK或EK病史进行分组，随访6个月。对两个队列进行倾向评分匹配，以控制年龄指数、性别、种族、民族以及Fuchs营养不良症和圆锥角膜的诊断。评估术后6个月随访期间急性CME的发生率。计算各组间的优势比。摘要：结果：共纳入2516只眼（PK: 1258; EK: 1258）。术后6个月，EK组（1258例中的46例）的急性CME发生率显著高于PK组（1258例中的20例）（P = 0.0012）（OR 0.426, 95%可信区间为0.25-0.72）。摘要：结论：我们的研究结果表明，与PK相比，EK患者的急性CME发生率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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