Clinical Profiles of Hospitalized Middle Eastern Patients With Nonvalvular Atrial Fibrillation: Analysis From the JoFib Study.

IF 0.7 Q2 PERIPHERAL VASCULAR DISEASE

International Journal of Vascular Medicine Pub Date : 2026-08-07 eCollection Date: 2026-01-01 DOI:10.1155/ijvm/6426995

Abdullah Al-Kasasbeh, Ahmad Abdalmajeed Alghzawi, Amr Alfakhouri, Nazih Kadri, Ammar Aloqaily, Mohammad Al-Oakily, Baha Awad, Ayman J Hammoudeh

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Abstract

Background: Atrial fibrillation (AF) is the most prevalent sustained arrhythmia and is associated with significant morbidity and mortality. Data on AF in hospitalized patients in the Middle East are limited.

Methods: We analyzed 536 hospitalized patients with nonvalvular AF from the Jordan atrial fibrillation (JoFib) registry. A prospective multicenter study of 2020 patients enrolled between May 2019 and December 2020. Patients were stratified into new-onset atrial fibrillation (NOAF) and previously diagnosed AF, and their clinical characteristics and in-hospital outcomes were compared.

Results: The cohort had a mean age of 70.2 ± 14.1 years, and 48.7% were male. The most common comorbidities were hypertension (77.6%), diabetes (52.1%), and heart failure (31.3%). NOAF patients were significantly younger and more likely to be smokers, whereas those with prior AF had more comorbidities and larger left atrial size. Overall, in-hospital mortality was 6.7% but was significantly higher in NOAF patients.

Conclusions: Hospitalized patients with NOAF are younger, more often smokers, and face higher in-hospital mortality compared with chronic AF, underscoring the need for early recognition and risk factor modification to prevent hospitalization.

Trial registration: ClinicalTrials.gov Identifier: NCT03917992.

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中东住院非瓣膜性心房颤动患者的临床概况：来自JoFib研究的分析

背景：心房颤动（AF）是最常见的持续性心律失常，具有显著的发病率和死亡率。中东地区住院患者房颤数据有限。方法：我们分析了约旦房颤（JoFib）登记的536例非瓣膜性房颤住院患者。一项前瞻性多中心研究，在2019年5月至2020年12月期间招募了2020名患者。将患者分为新发房颤（NOAF）和既往诊断房颤（AF），比较其临床特征和住院结果。结果：该队列平均年龄为70.2±14.1岁，男性48.7%。最常见的合并症是高血压（77.6%）、糖尿病（52.1%）和心力衰竭（31.3%）。NOAF患者明显更年轻，更有可能是吸烟者，而先前有AF的患者有更多的合并症和更大的左心房大小。总体而言，住院死亡率为6.7%，但NOAF患者的住院死亡率明显更高。结论：与慢性房颤相比，NOAF住院患者更年轻，更多的是吸烟者，并且面临更高的住院死亡率，强调需要早期识别和改变危险因素以防止住院。试验注册：ClinicalTrials.gov标识符：NCT03917992。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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