The many facets of Kaposi sarcoma-associated herpesvirus/human herpes virus-8 multicentric Castleman disease: clinical spectrum, diagnostic innovations, and therapeutic management.

IF 2.4 4区医学 Q2 ONCOLOGY

Current Opinion in Oncology Pub Date : 2026-09-01 Epub Date: 2026-07-27 DOI:10.1097/CCO.0000000000001258

David Boutboul, Romain Stammler, Yannick Dieudonné

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引用次数: 0

Abstract

Background: Castleman diseases encompass three distinct entities: unicentric Castleman disease, KSHV/HHV-8-associated multicentric Castleman disease (MCD), and idiopathic MCD. HHV-8 MCD is a life-threatening B-cell lymphoproliferative disorder driven by KSHV/HHV-8 infection of B cells, resulting in systemic inflammation and diverse clinical phenotypes.

Objective: To summarize current knowledge of HHV-8 MCD pathogenesis, clinical presentations, autoimmune complications, and diagnostic advances.

Methods: This review synthesizes existing literature on HHV-8 MCD, with particular attention to emerging diagnostic techniques, including liquid-phase detection of circulating viroblasts.

Results: Treatment approaches center on rituximab-based regimens, with outcomes varying between HIV-positive and HIV-negative populations. Novel diagnostic tools combining flow cytometry and viral transcript detection offer rapid identification of disease flares.

Conclusion: These emerging diagnostic approaches may improve management of HHV-8 MCD, particularly in emergency settings where rapid flare identification is critical.

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卡波西肉瘤相关疱疹病毒/人类疱疹病毒-8多中心Castleman病的诸多方面：临床谱、诊断创新和治疗管理

背景：Castleman疾病包括三种不同的实体：单中心Castleman病、KSHV/ hhv -8相关的多中心Castleman病（MCD）和特发性MCD。HHV-8 MCD是一种由KSHV/HHV-8感染B细胞驱动的危及生命的B细胞淋巴增殖性疾病，导致全身性炎症和多种临床表型。目的：总结目前对HHV-8型MCD发病机制、临床表现、自身免疫并发症及诊断进展的认识。方法：本文综述了现有关于HHV-8 MCD的文献，特别关注新兴的诊断技术，包括循环成病毒细胞的液相检测。结果：治疗方法以以利妥昔单抗为基础的方案为中心，hiv阳性和hiv阴性人群的结果不同。结合流式细胞术和病毒转录检测的新型诊断工具可以快速识别疾病爆发。结论：这些新兴的诊断方法可以改善HHV-8 MCD的管理，特别是在紧急情况下，快速识别耀斑是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Oncology 医学-肿瘤学

CiteScore

6.10

自引率

2.90%

发文量

130

审稿时长

4-8 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.