The Critical Role of Serial β-hCG Monitoring in Diagnosing Bilateral Tubal Pregnancy Following Conservative Surgery.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2026-08-01 DOI:10.7754/Clin.Lab.2025.251156

Yaowen Hu, Qun Fang

{"title":"The Critical Role of Serial β-hCG Monitoring in Diagnosing Bilateral Tubal Pregnancy Following Conservative Surgery.","authors":"Yaowen Hu, Qun Fang","doi":"10.7754/Clin.Lab.2025.251156","DOIUrl":null,"url":null,"abstract":"Background: Bilateral tubal pregnancy (BTP) is a rare and diagnostically challenging form of ectopic pregnancy. This report emphasizes the critical importance of serial beta-human chorionic gonadotropin (β-hCG) surveillance following conservative tubal surgery.Methods: A 29-year-old patient underwent laparoscopic salpingostomy for a right tubal pregnancy. Serial β-hCG measurements were performed postoperatively to monitor trophoblastic activity.Results: Instead of the expected decline, β-hCG levels rose postoperatively (from 809.29 mIU/mL to 942.47 mIU/mL by day 3). This abnormal trend prompted re-evaluation, leading to the identification of a contralateral tubal pregnancy via ultrasonography. Surgical intervention confirmed the diagnosis of BTP. Following the second procedure, β-hCG levels normalized within one month.Conclusions: Systematic postoperative β-hCG monitoring is essential for the early detection of persistent ectopic pregnancy and rare conditions like BTP. This case demonstrates that vigilant laboratory surveillance can trigger crucial clinical reassessment, thereby preventing diagnostic oversight and guiding effective management.","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 8","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2025.251156","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Bilateral tubal pregnancy (BTP) is a rare and diagnostically challenging form of ectopic pregnancy. This report emphasizes the critical importance of serial beta-human chorionic gonadotropin (β-hCG) surveillance following conservative tubal surgery.

Methods: A 29-year-old patient underwent laparoscopic salpingostomy for a right tubal pregnancy. Serial β-hCG measurements were performed postoperatively to monitor trophoblastic activity.

Results: Instead of the expected decline, β-hCG levels rose postoperatively (from 809.29 mIU/mL to 942.47 mIU/mL by day 3). This abnormal trend prompted re-evaluation, leading to the identification of a contralateral tubal pregnancy via ultrasonography. Surgical intervention confirmed the diagnosis of BTP. Following the second procedure, β-hCG levels normalized within one month.

Conclusions: Systematic postoperative β-hCG monitoring is essential for the early detection of persistent ectopic pregnancy and rare conditions like BTP. This case demonstrates that vigilant laboratory surveillance can trigger crucial clinical reassessment, thereby preventing diagnostic oversight and guiding effective management.

查看原文本刊更多论文

β-hCG系列监测在保守手术后双侧输卵管妊娠诊断中的关键作用。

背景：双侧输卵管妊娠（BTP）是一种罕见且诊断困难的异位妊娠形式。本报告强调了保守输卵管手术后连续监测β-人绒毛膜促性腺激素（β-hCG）的重要性。方法：29岁患者行腹腔镜输卵管造口术治疗右侧输卵管妊娠。术后进行一系列β-hCG测量以监测滋养细胞活性。结果：术后β-hCG水平非但没有预期的下降，反而上升（第3天从809.29 mIU/mL上升到942.47 mIU/mL）。这种异常趋势促使重新评估，导致通过超声检查确定对侧输卵管妊娠。手术治疗证实了BTP的诊断。在第二次手术后，β-hCG水平在一个月内恢复正常。结论：系统的术后β-hCG监测对于早期发现持续性异位妊娠和BTP等罕见情况至关重要。该病例表明，警惕的实验室监测可以引发关键的临床重新评估，从而防止诊断疏忽并指导有效的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.