Screening and Diagnostic Strategies for Sarcomatoid Carcinoma of the Pancreas.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2026-08-01 DOI:10.7754/Clin.Lab.2025.250841

Jian-Hao Zhang, Qiu-Bo Xu

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引用次数: 0

Abstract

Background: Sarcomatoid carcinoma of the pancreas (SCP) is an exceptionally rare variant of pancreatic ductal adenocarcinoma. A detailed evaluation of its clinical manifestations, laboratory findings, and imaging characteristics may contribute to earlier detection and intervention, thereby improving survival outcomes and quality of life.

Methods: We retrospectively reviewed the clinical presentation, laboratory investigations, and imaging findings of a patient with pathologically confirmed SCP. In addition, relevant literature was analyzed to summarize strategies for early screening and diagnosis.

Results: A 78-year-old female presented with persistent dull epigastric pain accompanied by nausea and vomiting. Laboratory evaluation revealed elevated CA19-9 levels. Imaging demonstrated a mass in the pancreatic body and tail. Dynamic contrast-enhanced CT showed moderate heterogeneous enhancement in the arterial phase with progressive enhancement during the portal venous phase. Dynamic contrast-enhanced MRI revealed rim enhancement.

Conclusions: The integration of serum CA19-9 measurement with characteristic imaging features may facilitate the early identification of SCP.

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胰腺肉瘤样癌的筛查和诊断策略。

背景：胰腺肉瘤样癌（SCP）是一种非常罕见的胰腺导管腺癌。对其临床表现、实验室结果和影像学特征的详细评估可能有助于早期发现和干预，从而改善生存结果和生活质量。方法：回顾性分析1例经病理证实的SCP患者的临床表现、实验室检查和影像学表现。并对相关文献进行分析，总结早期筛查和诊断的策略。结果：一名78岁女性，表现为持续隐痛的上腹部疼痛并伴有恶心和呕吐。实验室检查显示CA19-9水平升高。影像学显示胰腺体和尾部有肿块。动态增强CT显示动脉期中度不均匀增强，门静脉期渐进式增强。动态增强MRI显示边缘增强。结论：将血清CA19-9检测与特征性影像学特征相结合，有助于SCP的早期诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.