A molecularly imprinted electrochemical aptasensor based on graphene and tin dioxide composite with electrodeposited gold nanoparticles for dual recognition of enrofloxacin.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2027-02-01 Epub Date: 2026-08-03 DOI:10.1016/j.talanta.2026.130391

Ying Wang, Shanshan Fu, Zhengyuan Dai, Yinuo Liu, Xiaoyu Yang, Li Li, Yaping Ding

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引用次数: 0

Abstract

In this work, a molecularly imprinted electrochemical aptamer sensor (MIEAS) for the detection of enrofloxacin (ENR) was developed using SnO₂-graphene (SnO₂-Gr) and gold nanoparticles (AuNPs) as electrode modification materials. The SnO₂-Gr composite material has a large specific surface area and can enhance the conductivity of the sensing platform. The aptamer, serving as a biofunctional monomer, was immobilized on the electrode surface via Au-S bonds. Using ENR as the template molecule and nicotinamide (NA) as the chemical functional monomer, a molecularly imprinted polymer (MIP) film was prepared by electropolymerization. Benefiting from the synergistic effect of MIP and aptamer, this MIEAS exhibits a good linear relationship with ENR in the range of 10^-14 to 10^-5 M, and the detection limit is as low as 1.65 × 10^-15 M. Satisfactory recovery was obtained in milk and environmental water samples, indicating the potential for application in food and environmental analysis.

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基于石墨烯和二氧化锡复合材料的分子印迹电化学传感器及其对恩诺沙星的双重识别。

本研究以sno2 -石墨烯（SnO2-Gr）和金纳米颗粒（AuNPs）为电极修饰材料，开发了用于检测恩诺沙星（ENR）的分子印迹电化学适体传感器（MIEAS）。SnO2-Gr复合材料具有较大的比表面积，可以提高传感平台的导电性。该适体作为一种生物功能单体，通过Au-S键固定在电极表面。以ENR为模板分子，烟酰胺（NA）为化学功能单体，采用电聚合法制备了分子印迹聚合物（MIP）膜。得益于MIP和适体的协同作用，该MIEAS与ENR在10-14 ~ 10-5 M范围内呈良好的线性关系，检出限低至1.65 × 10-15 M。在牛奶和环境水样中获得了满意的回收率，表明了在食品和环境分析中的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.