Addressing the potential side effects and safety of daily oral administration of Siberian ginseng

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Equine Veterinary Education Pub Date : 2026-08-05 Epub Date: 2026-06-26 DOI:10.1111/eve.70137

F. M. Andrews, A. M. Chapman, J. Cremer, M. L. Keowen, F. Garza Jr, C.-C. Liu, L. Gray

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引用次数: 0

Abstract

Background

Supplements containing Siberian ginseng (SBG; Eleutherococcus senticosus, ‘eleuthero’) are administered to horses to maintain health and wellbeing. SBG has been reported to cause hypertension, anxiety and hypoglycaemia in other species, but there are no published reports documenting adverse events in horses.

Objectives

The objective of the study was to determine if the administration of a supplement containing SBG results in hypertension, hyperactivity, anxiety and/or hypoglycaemia in horses.

Methods

Sixteen clinically healthy adult horses, housed in stalls and randomly assigned to treated (N = 8; pellets containing SBG, 1000 mg, fed daily for 29 days) or control (N = 8; pellets without SBG) groups. Blood work was evaluated on days 1 and 28 after daily feeding. Blood pressure and movement in the stall were measured before and for 3 h after feeding the pellets on days 1, 14 and 28. Horses were subjected to a novel object test (NOT) on day 0, before feeding the pellets and day 29, 2 h after administering the supplement. Anxiety scores to the NOT were assigned by a masked observer. Horses were monitored daily for adverse events.

Results

The supplement was readily consumed by the horses and no adverse effects were seen over the treatment period. Mean systolic blood pressure was significantly (p < 0.05) decreased in the SBG-treated group by day 14 and 28 when compared to day 1 and on day 28 compared to controls. Anxiety scores, after the NOT, were not significantly different between groups. There were no treatment effects on heart rate, blood values, including glucose, indicators of anaemia and blood proteins, liver enzymes, kidney values, electrolytes, calcium or bodyweight.

Conclusions

The supplement containing Siberian ginseng (1000 mg, once daily) was readily consumed and the administration for 29 days did not cause health issues, or result in hypertension, increased anxiety or hypoglycaemia.

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探讨西伯利亚人参日常口服的潜在副作用和安全性

含有西伯利亚人参的补品（SBG；刺棘球绦虫，刺棘球绦虫）被给予马以保持健康和福祉。据报道，在其他物种中，SBG会引起高血压、焦虑和低血糖，但没有发表的报告记录了马的不良事件。本研究的目的是确定服用含有SBG的补充剂是否会导致马的高血压、多动症、焦虑和/或低血糖。方法16匹临床健康成年马，饲养于马厩内，随机分为治疗组（N = 8，含SBG颗粒，1000 mg，每日饲喂29 d）和对照组（N = 8，不含SBG颗粒）。每日饲喂后第1天和第28天进行血液检查。分别于第1、14、28天饲喂微丸前和饲喂后3 h测量马厩内血压和活动量。马在第0天饲喂颗粒前和第29天饲喂补充剂后2小时进行新对象试验（NOT）。非被试者的焦虑分数是由一个蒙面的观察者分配的。每天监测马匹的不良事件。结果该补品易于马消化，治疗期间未见不良反应。与第1天和第28天相比，sbg治疗组的平均收缩压在第14天和第28天与对照组相比显著降低（p < 0.05）。在NOT之后，两组之间的焦虑得分没有显著差异。对心率、血值（包括葡萄糖）、贫血指标和血蛋白、肝酶、肾值、电解质、钙或体重没有治疗效果。结论西伯利亚人参补充剂（1000 mg，每日1次）易于食用，连续服用29天未引起健康问题，也未导致高血压、焦虑增加或低血糖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Equine Veterinary Education 农林科学-兽医学

CiteScore

2.40

自引率

22.20%

发文量

132

审稿时长

18-36 weeks

期刊介绍： Equine Veterinary Education (EVE) is the official journal of post-graduate education of both the British Equine Veterinary Association (BEVA) and the American Association of Equine Practitioners (AAEP). Equine Veterinary Education is a monthly, peer-reviewed, subscription-based journal, integrating clinical research papers, review articles and case reports from international sources, covering all aspects of medicine and surgery relating to equids. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of equine medicine and surgery. The educational value of a submitted article is one of the most important criteria that are assessed when deciding whether to accept it for publication. Articles do not necessarily need to contain original or novel information but we welcome submission of this material. The educational value of an article may relate to articles published with it (e.g. a Case Report may not have direct educational value but an associated Clinical Commentary or Review Article published alongside it will enhance the educational value).