Functional heterogeneity across structural MRI-based atrophy subtypes in Alzheimer's disease.

IF 6 2区医学 Q1 GERIATRICS & GERONTOLOGY

International psychogeriatrics Pub Date : 2026-08-07 DOI:10.1016/j.inpsyc.2026.100255

Dong Xu, Huanhuan Zhang, Zhiyan Piao, Yong He, Haiyan Li, Nan Zhang

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引用次数: 0

Abstract

Objectives: This study explored whether distinct Alzheimer's disease (AD) structural atrophy subtypes exhibit divergent functional profiles.

Design: A cross-sectional multimodal neuroimaging and electrophysiological study.

Setting: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.

Participants: A total of 116 patients with AD and 74 cognitively unimpaired controls underwent structural MRI. Patients with AD were stratified into three MRI-derived atrophy-pattern groups corresponding to hippocampal-sparing (HpSp-MRI), typical (tAD-MRI), and limbic-predominant (LP-MRI) subtypes.

Measurements: Resting-state functional MRI was used to assess intra- and internetwork functional connectivity, and EEG was used to evaluate spectral power and microstate dynamics.

Results: The HpSp-MRI subtype showed lower intranetwork connectivity than both the LP-MRI and tAD-MRI subtypes in the visual, somatomotor, and dorsal attention networks. The LP-MRI and tAD-MRI subtypes differed in ventral attention network connectivity. Moreover, the LP-MRI subtype exhibited stronger internetwork connectivity in specific network pairs compared with the other subtypes. EEG analysis suggested a possible difference in the microstate 3-to-1 transition between the LP-MRI and tAD-MRI groups.

Conclusions: MRI-derived atrophy-pattern subtypes showed different resting-state functional connectivity profiles, providing a potential basis for personalized brain network-targeted interventions in AD.

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阿尔茨海默病中基于结构mri的萎缩亚型的功能异质性。

目的：本研究探讨不同的阿尔茨海默病（AD）结构萎缩亚型是否表现出不同的功能特征。设计：横断面多模态神经成像和电生理研究。单位：天津医科大学总医院神经内科。参与者：共116名AD患者和74名认知功能未受损的对照组接受了结构MRI检查。阿尔茨海默病患者被分为三个mri衍生的萎缩模式组，分别是海马保留（hsp - mri）、典型（tAD-MRI）和边缘优势（LP-MRI）亚型。测量方法：静息状态功能MRI用于评估网络内部和网络之间的功能连通性，EEG用于评估频谱功率和微状态动力学。结果：hsp - mri亚型在视觉、躯体运动和背侧注意网络中的连通性低于LP-MRI和tAD-MRI亚型。LP-MRI和tAD-MRI亚型在腹侧注意网络连通性上存在差异。此外，与其他亚型相比，LP-MRI亚型在特定网络对中表现出更强的网络连通性。脑电图分析表明LP-MRI组和tAD-MRI组之间的微观状态3- 1转换可能存在差异。结论：mri衍生的萎缩模式亚型显示出不同的静息状态功能连接谱，为针对AD的个性化脑网络干预提供了潜在的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International psychogeriatrics 医学-精神病学

CiteScore

9.10

自引率

8.60%

发文量

217

审稿时长

3-6 weeks

期刊介绍： A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.