Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2026-08-07 DOI:10.1111/bdi.70166

Rebecca Marks, Anjali Sankar, Lejla Colic, Jair Soares, Joaquim Radua, Eduard Vieta, Benson Mwangi, Mon-Ju Wu, Enric Vilajosana, Edith Pomarol-Clotet, Erick Canales-Rodríguez, Raymond Salvador, Brian Pittman, Annemieke Dols, Martha Sajatovic, Lisa T. Eyler, Hilary P. Blumberg

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引用次数: 0

Abstract

Background

Older adults with bipolar disorder (BD) are at high risk for severe mood symptoms, cognitive difficulties, and early mortality; however, underlying brain alterations have received little study. Gray matter decreases in ventral prefrontal cortex (VPFC) seen in younger persons with BD, and additionally in dorsal PFC (DPFC), are implicated. Here, cortical thickness was examined in an international sample.

Methods

Cortical thickness in 34 regions was measured from structural magnetic resonance imaging data using enhancing neuroImaging genetics through meta-analysis pipelines for individuals with BD (n = 308) and non-psychiatric comparison participants (n = 287), ages 40–70y, from six Global Aging and Geriatric Experiments in BD (GAGE-BD) consortium sites. Group differences were assessed for VPFC, DPFC and remaining cortical regions, covarying for scanner, age and sex. Results were considered significant corrected for false discovery fate (FDR) at p_FDR < 0.05. Relationships with demographic and clinical factors were explored.

Results

Cortical thickness was significantly lower among BD in VPFC and DPFC, and additional distributed regions (p_FDR < 0.05) and negatively associated with age (p < 0.05); group and age did not interact significantly. Relationships with BD subtype and medications were observed; lithium was associated with higher frontal pole and anterior cingulate thickness (p_FDR < 0.05).

Conclusions

In this international middle and older aged adult BD sample, lower VPFC cortical thickness was observed, suggesting these deficits persist from younger age. DPFC and additional regions of reduced cortical thickness could contribute to the older adult BD phenotype. Cortical thinning was more pronounced among older individuals regardless of diagnosis. Lithium may lessen cortical thinning.

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六个国际研究中心的中老年双相情感障碍患者的皮质厚度。

背景：老年双相情感障碍（BD）患者有严重情绪症状、认知困难和早期死亡的高风险；然而，潜在的大脑改变却很少得到研究。在年轻的双相障碍患者中，腹侧前额叶皮层（VPFC）和背侧前额叶皮层（DPFC）的灰质减少与此有关。这里，在一个国际样本中检查了皮质厚度。方法：采用增强神经成像遗传学的meta分析方法，通过结构磁共振成像数据测量34个区域的皮质厚度，这些数据来自6个全球衰老和老年痴呆症（GAGE-BD）联盟地点的BD患者（n = 308）和非精神病学对照参与者（n = 287），年龄在40-70岁之间。评估VPFC， DPFC和剩余皮质区域的组间差异，扫描仪，年龄和性别共变。结果被认为是对pFDR错误发现（FDR）的显著纠正结果：在VPFC和DPFC以及其他分布区域（pFDR FDR）中，BD的皮质厚度明显较低结论：在这个国际中老年BD样本中，观察到较低的VPFC皮质厚度，表明这些缺陷从年轻时开始持续存在。DPFC和皮质厚度减少的其他区域可能有助于老年人BD表型。无论诊断如何，皮质变薄在老年人中更为明显。锂可以减轻皮质变薄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.