Ko Kadowaki, Shin Nishimura, Akihiro Toyoda, Ryuhei Yamamoto
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引用次数: 0
Abstract
Objective: To report tumor response, complications, outcomes, and extrahepatic collateral arterial supply presence in dogs with massive hepatocellular carcinoma (HCC) treated with transcatheter arterial embolization (TAE).
Animals: 18 dogs diagnosed with massive HCC.
Clinical presentation: All dogs underwent contrast-enhanced CT and pretreatment histopathologic confirmation by laparoscopic biopsy (n = 1) or ultrasound-guided needle core biopsy (17). Tumor response was assessed using percentage of change in tumor volume on CT before TAE and 1 to 3 months after TAE.
Results: Post-TAE tumor response was classified as partial response in 9 of 18 (50.0%), stable disease in 6 of 18 (33.3%), and progressive disease in 1 of 18 (5.6%). Two dogs (11.1%) died within 2 weeks after TAE. The median percentage of change in tumor volume, excluding those 2 dogs, was -32.6%. Extrahepatic collateral arterial supplies to tumors were identified in 13 of 18 (72.2%), including the gastroepiploic (22.2%), right phrenic (22.2%), left phrenic (27.8%), pancreatic (16.7%), and mesenteric (5.6%) arteries. Collateral supply from 2 and 3 vessels was observed in 3 of 18 (16.7%) and 1 of 18 (5.6%), respectively; second TAE was performed in 2 of 18 (11.1%) and hepatic lobectomy after TAE in 4 of 18 (22.2%) cases. Postoperative complications included mild diarrhea (77.8%), anorexia (61.1%), mild anemia (16.7%), and acute gallbladder infarction (11.1%) etc. Both cases of gallbladder infarction were asymptomatic with good clinical outcomes. Median survival time was 447 days, including all 18 dogs. Transcatheter arterial embolization achieved disease control in most dogs and often involved extrahepatic collaterals.
Clinical relevance: TAE may be a useful option in selected dogs with massive HCC.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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