Ram Sanath-Kumar, Qin Liao, Zhongqing Ren, Xindan Wang
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引用次数: 0
Abstract
Structural maintenance of chromosomes (SMC) complexes are conserved ATP-driven machines that organize, compact, and segregate genomes in all domains of life. Despite variation in subunit composition and regulation, all SMC complexes share a core structure and mechanism of action. Bacteria possess two major classes of SMC complexes, SMC-ScpAB and MukBEF, which function in chromosome compaction and segregation. In addition, some bacteria contain other SMC complexes or SMC-like systems such as MksBEF, Wadjet, RecN, and SbcC, each with specialized functions. Bacterial SMC complexes coordinate genome maintenance, DNA replication, DNA repair, plasmid defense, and cell physiology. In this review, we discuss the structure and function of these bacterial SMC complexes, highlighting the shared characteristics and unique strategies employed by each.
期刊介绍：
Annual Review of Microbiology is a Medical and Microbiology Journal and published by Annual Reviews Inc. The Annual Review of Microbiology, in publication since 1947, covers significant developments in the field of microbiology, encompassing bacteria, archaea, viruses, and unicellular eukaryotes. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The Impact Factor of Annual Review of Microbiology is 10.242 (2024) Impact factor. The Annual Review of Microbiology Journal is Indexed with Pubmed, Scopus, UGC (University Grants Commission).
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