Role of sex and ethnicity in the relationships among physical activity, cognition, and AD biomarkers in the HABS-HD cohort.

IF 4.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-06 eCollection Date: 2026-07-01 DOI:10.1002/dad2.70437

Jansie H Nel, Joel S Burma, Tamara S Bodnar, Meghan McDonough, Gregory Knell, Melissa Petersen, Sid E O'Bryant, Cindy K Barha

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引用次数: 0

Abstract

Introduction: Dementia prevalence is rising with population aging, disproportionately affecting females and ethnically diverse groups. Physical activity (PA) may mitigate age-related cognitive and brain decline; sex- and ethnicity-specific associations remain poorly understood.

Methods: Data from the Health and Aging Brain Study-Health Disparities were analyzed from 3585 participants (63% female). PA was categorized using the Rapid Assessment of Physical Activity (RAPA) questionnaire as no/little (< 4) or moderate/high (≥ 4). Outcomes included cognitive composites, plasma biomarkers, and magnetic resonance imaging-derived hippocampal subregions and dorsolateral prefrontal cortex volumes.

Results: Higher PA was associated with higher global cognition and executive functions in all females and in Hispanic males (ps < 0.05), higher episodic memory and larger hippocampal volumes across participants (ps < 0.05), and lower amyloid beta 40, total tau, and larger hippocampal subregion volumes in females (ps < 0.05).

Conclusions: Findings support PA as a modifiable factor associated with healthy brain aging, emphasizing the importance of incorporating sex and ethnicity into future research.

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性别和种族在HABS-HD队列中身体活动、认知和AD生物标志物之间的关系中的作用

导读：随着人口老龄化，痴呆症患病率正在上升，对女性和不同种族群体的影响尤为严重。体育活动（PA）可能减轻与年龄相关的认知和大脑衰退；性别和种族特定的关联仍然知之甚少。方法：对3585名参与者（63%为女性）的健康与衰老脑研究数据进行分析。使用体能活动快速评估（RAPA）问卷将PA分类为无/少(结果：在所有女性和西班牙裔男性中，PA较高与较高的全球认知和执行功能相关（ps ps ps）结论：研究结果支持PA是与健康大脑衰老相关的可改变因素，强调了将性别和种族纳入未来研究的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.