{"title":"Charge-cloud-based micrometer resolution in deep-silicon photon-counting CT.","authors":"Rickard Brunskog, Mats Persson, Moa Yveborg Tamm, Umberto Follo, Mats Danielsson","doi":"10.1117/1.JMI.13.4.043501","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We are developing a monolithic deep-silicon photon-counting sensor targeting spatial resolution on the order of <math><mrow><mn>1</mn> <mtext> </mtext> <mi>μ</mi> <mi>m</mi></mrow> </math> . This work investigates how pixel pitch, noise level, threshold number, and threshold placement affect the achievable tangential and wafer-thickness resolution to guide the CMOS electronics and sensor design.</p><p><strong>Approach: </strong>Allpix Squared simulations were used to evaluate pixel pitches with two noise levels and two threshold-placement schemes over varying threshold numbers. Interaction position was estimated in both dimensions using lookup tables trained on the thresholded pixel output, and performance was quantified using the MTF.</p><p><strong>Results: </strong>Decreasing pixel pitch strongly improved tangential resolution for Compton interactions, whereas photoelectric interactions showed a weaker dependence on pixel pitch and threshold placement. Equal-counting thresholds approached the achievable resolution with fewer thresholds than equidistant thresholds. For eight equal-counting thresholds, the 10% MTF across the studied pixel sizes ranged from <math><mrow><mtext>1284 </mtext> <mrow><mi>lp</mi></mrow> <mo>/</mo> <mi>cm</mi></mrow> </math> to <math><mrow><mtext>2452 </mtext> <mrow><mi>lp</mi></mrow> <mo>/</mo> <mi>cm</mi></mrow> </math> in the tangential direction and from 15 to <math><mrow><mn>71</mn> <mtext> </mtext> <mrow><mi>lp</mi></mrow> <mo>/</mo> <mi>cm</mi></mrow> </math> in the wafer-thickness direction for Compton interactions, compared with 409 to <math><mrow><mn>507</mn> <mtext> </mtext> <mrow><mi>lp</mi></mrow> <mo>/</mo> <mi>cm</mi></mrow> </math> and 18 to <math><mrow><mn>79</mn> <mtext> </mtext> <mrow><mi>lp</mi></mrow> <mo>/</mo> <mi>cm</mi></mrow> </math> , respectively, for photoelectric interactions. RMSE analysis further showed that some interactions for the <math><mrow><mn>25</mn> <mtext> </mtext> <mi>μ</mi> <mi>m</mi></mrow> </math> pitch reached below <math><mrow><mn>2</mn> <mtext> </mtext> <mi>μ</mi> <mi>m</mi></mrow> </math> tangentially and a few tens of micrometers in the wafer-thickness direction.</p><p><strong>Conclusions: </strong>Spatial resolution improved with a threshold number up to about 8 to 10, beyond which additional programmable thresholds gave only modest gain. The achieved tangential resolution also suggests that analyzer-free phase-contrast imaging is feasible for realistic geometries and expected interference patterns.</p>","PeriodicalId":47707,"journal":{"name":"Journal of Medical Imaging","volume":"13 4","pages":"043501"},"PeriodicalIF":2.3000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446572/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1117/1.JMI.13.4.043501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: We are developing a monolithic deep-silicon photon-counting sensor targeting spatial resolution on the order of . This work investigates how pixel pitch, noise level, threshold number, and threshold placement affect the achievable tangential and wafer-thickness resolution to guide the CMOS electronics and sensor design.
Approach: Allpix Squared simulations were used to evaluate pixel pitches with two noise levels and two threshold-placement schemes over varying threshold numbers. Interaction position was estimated in both dimensions using lookup tables trained on the thresholded pixel output, and performance was quantified using the MTF.
Results: Decreasing pixel pitch strongly improved tangential resolution for Compton interactions, whereas photoelectric interactions showed a weaker dependence on pixel pitch and threshold placement. Equal-counting thresholds approached the achievable resolution with fewer thresholds than equidistant thresholds. For eight equal-counting thresholds, the 10% MTF across the studied pixel sizes ranged from to in the tangential direction and from 15 to in the wafer-thickness direction for Compton interactions, compared with 409 to and 18 to , respectively, for photoelectric interactions. RMSE analysis further showed that some interactions for the pitch reached below tangentially and a few tens of micrometers in the wafer-thickness direction.
Conclusions: Spatial resolution improved with a threshold number up to about 8 to 10, beyond which additional programmable thresholds gave only modest gain. The achieved tangential resolution also suggests that analyzer-free phase-contrast imaging is feasible for realistic geometries and expected interference patterns.
期刊介绍:
JMI covers fundamental and translational research, as well as applications, focused on medical imaging, which continue to yield physical and biomedical advancements in the early detection, diagnostics, and therapy of disease as well as in the understanding of normal. The scope of JMI includes: Imaging physics, Tomographic reconstruction algorithms (such as those in CT and MRI), Image processing and deep learning, Computer-aided diagnosis and quantitative image analysis, Visualization and modeling, Picture archiving and communications systems (PACS), Image perception and observer performance, Technology assessment, Ultrasonic imaging, Image-guided procedures, Digital pathology, Biomedical applications of biomedical imaging. JMI allows for the peer-reviewed communication and archiving of scientific developments, translational and clinical applications, reviews, and recommendations for the field.