{"title":"A Solitary Soft Tissue Mass in the Thigh as the First Manifestation of Occult Lung Squamous Cell Carcinoma: A Case Report.","authors":"Jian Gao, MengWei Zhang, YuYing Li","doi":"10.1002/rcr2.70713","DOIUrl":null,"url":null,"abstract":"<p><p>A 69-year-old male patient developed a painless, gradually increasing mass in the upper part of his right thigh, with no pulmonary symptoms. Magnetic resonance imaging revealed a nodular lesion in the lateral femoral muscle, which was initially suspected to be a primary soft tissue tumour. After the mass was surgically removed, the histopathological examination confirmed squamous cell carcinoma (SCC), and the immunohistochemical staining of P63 and CK5/6 was positive. Subsequent FDG PET/CT examination revealed a hypermetabolic nodule in the upper lobe of the right lung. Endobronchial ultrasound-guided biopsy confirmed it as primary lung SCC. This case indicates that isolated skeletal muscle metastasis can be the initial manifestation of occult lung cancer. The research results suggest that seemingly isolated soft tissue masses may be the first sign of latent malignant tumours.</p>","PeriodicalId":45846,"journal":{"name":"Respirology Case Reports","volume":"14 8","pages":"e70713"},"PeriodicalIF":0.7000,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445779/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/rcr2.70713","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/8/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
A 69-year-old male patient developed a painless, gradually increasing mass in the upper part of his right thigh, with no pulmonary symptoms. Magnetic resonance imaging revealed a nodular lesion in the lateral femoral muscle, which was initially suspected to be a primary soft tissue tumour. After the mass was surgically removed, the histopathological examination confirmed squamous cell carcinoma (SCC), and the immunohistochemical staining of P63 and CK5/6 was positive. Subsequent FDG PET/CT examination revealed a hypermetabolic nodule in the upper lobe of the right lung. Endobronchial ultrasound-guided biopsy confirmed it as primary lung SCC. This case indicates that isolated skeletal muscle metastasis can be the initial manifestation of occult lung cancer. The research results suggest that seemingly isolated soft tissue masses may be the first sign of latent malignant tumours.
期刊介绍：
Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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