Gray Matter Structural Asymmetry and Premenstrual Dysphoric Disorder.

IF 3.7 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2026-08-06 DOI:10.1159/000553663

Elise Bücklein-Ehlers, Manon Dubol, Birgit Derntl, Melanies Henes, Ann-Christine Ehlis, Thomas Dresler, Inger Sundström-Poromaa, Andreas Fallgatter, Erika Comasco

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引用次数: 0

Abstract

Introduction: Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behavior, and vulnerability to mental disorders. Despite evidence for lateralized brain sensitivity to hormonal fluctuations, the cortical and subcortical asymmetry profile of individuals with premenstrual dysphoric disorder (PMDD), a hormone-related mood disorder associated with alterations in brain structure, remains unexplored.

Methods: In this study, a total of 68 females with PMDD and 51 healthy females underwent magnetic resonance imaging during the luteal phase of the menstrual cycle. Structural asymmetry was assessed using voxel-wise whole-brain analysis and region of interest (ROI) approaches for gray matter volume (GMV), as well as ROI-based analysis of cortical thickness. Associations between asymmetry and symptom severity were also investigated.

Results: Whole-brain analyses revealed significantly greater leftward GMV asymmetry in PMDD participants in two clusters within the anterior fusiform gyrus and the anterior insula. ROI-based analyses did not show any asymmetry group differences in either GMV or cortical thickness. Within the PMDD group, greater leftward asymmetry in the amygdala GMV was moderately associated with higher irritability.

Conclusion: These findings provide novel, region-specific evidence for structural asymmetry in PMDD and suggest that lateralized brain architecture may contribute to affective symptom expression in this disorder.

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灰质结构不对称与经前焦虑症。

导读：左右脑不对称是人类神经解剖学的一个重要特征，与认知、行为和精神障碍易感性有关。尽管有证据表明对激素波动有偏侧敏感性，但经前烦躁不安（PMDD）（一种与大脑结构改变相关的激素相关情绪障碍）患者的皮层和皮层下不对称特征仍未得到研究。方法：在本研究中，共68名经前不悦症女性和51名健康女性在月经周期的黄体期进行了磁共振成像（MRI）检查。使用体素全脑分析和灰质体积（GMV）感兴趣区域（ROI）方法以及基于ROI的皮质厚度分析来评估结构不对称性。不对称与症状严重程度之间的关系也被调查。结果：全脑分析显示，PMDD参与者在前梭状回和前岛内的两个集群中，GMV向左不对称显著增加。基于roi的分析在GMV或皮质厚度上没有显示任何不对称组的差异。在经前抑郁组中，杏仁核GMV向左偏大的不对称性与较高的易怒程度中度相关。结论：这些发现为经前不悦症的结构不对称提供了新的、区域特异性的证据，并提示偏侧的大脑结构可能有助于该疾病的情感症状表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.