Bianca Tavares Rangel, Amanda Aparecida Maia Neves Garcia, Carolina Yoshi Campos Sugio, Vanessa Migliorini Urban, Simone Soares, Joel Ferreira Santiago Júnior, André Ulisses Dantas Batista, Karin Hermana Neppelenbroek
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引用次数: 0
Abstract
Objective: Despite the potential of nanofibers to reinforce poly(methyl methacrylate) (PMMA) denture base resins, no consensus exists regarding their effects on material properties. This systematic review and meta-analysis aimed to evaluate whether the incorporation of nanofibers into PMMA denture base resins improves flexural strength and other physicomechanical properties when compared with unmodified PMMA.
Methodology: This study followed PRISMA guidelines and was registered on the Open Science Framework (). Searches were conducted on Medline/PubMed, Scopus, Cochrane Library, Web of Science, EMBASE, Lilacs, and SciELO. Eligibility criteria included in vitro or in vivo studies comparing nanofiber-reinforced PMMA to conventional PMMA. The meta-analysis was conducted for flexural strength (the only property assessed in all studies). A subgroup meta-analysis was performed to explore heterogeneity between studies.
Results: From the 1,893 initially screened articles, six were included. The investigated nanofibers included carbon, acrylonitrile-butadiene-styrene, polyamide-6, polystyrene, cellulose, PMMA-cerium, and polyvinyl alcohol at concentrations from 0.1 to 23%. The evaluated properties included impact strength, flexural strength, fracture resistance, hardness, elasticity, toughness, surface roughness, contact angle, and spectrophotometric color analysis. While the qualitative analysis showed divergent findings regarding property improvement, the quantitative analysis revealed no significant differences in flexural strength between nanofiber-reinforced PMMA and conventional PMMA at the evaluated concentrations: PMMA vs. 0.5% PMMA (p=0.554), PMMA vs. 1% PMMA (p=0.847), PMMA vs. 3% PMMA (p=0.9825), and PMMA vs. 5% PMMA (p=0.222). However, subgroup analysis indicated higher flexural strength for the conventional PMMA when compared with nanofiber-reinforced PMMA, particularly at higher nanofiber concentrations (p<0.0001).
Conclusion: Incorporating nanofibers into PMMA resulted in no significant increase in flexural strength, showing inconsistent effects on other physicomechanical properties. Therefore, further standardized laboratory and clinical studies are needed to clarify its efficacy and clinical applicability.
目的：尽管纳米纤维具有增强聚甲基丙烯酸甲酯（PMMA）义齿基托树脂的潜力，但其对材料性能的影响尚未达成共识。本系统综述和荟萃分析旨在评估纳米纤维掺入PMMA义齿基托树脂与未改性PMMA相比是否能提高抗弯强度和其他物理力学性能。方法学：本研究遵循PRISMA指南，并在开放科学框架（）上注册。检索在Medline/PubMed、Scopus、Cochrane Library、Web of Science、EMBASE、Lilacs和SciELO上进行。资格标准包括比较纳米纤维增强PMMA与传统PMMA的体外或体内研究。荟萃分析是针对弯曲强度（所有研究中唯一评估的特性）进行的。进行亚组荟萃分析以探讨研究之间的异质性。结果：从1893篇最初筛选的文章中，6篇被纳入。所研究的纳米纤维包括碳、丙烯腈-丁二烯-苯乙烯、聚酰胺-6、聚苯乙烯、纤维素、pmma -铈和聚乙烯醇，浓度从0.1到23%不等。评估的性能包括冲击强度、弯曲强度、抗断裂性、硬度、弹性、韧性、表面粗糙度、接触角和分光光度颜色分析。虽然定性分析在性能改善方面显示出不同的结果，但定量分析显示，在评估浓度下，纳米纤维增强PMMA与常规PMMA在抗弯强度方面没有显著差异：PMMA vs. 0.5% PMMA (p=0.554), PMMA vs. 1% PMMA (p=0.847), PMMA vs. 3% PMMA (p=0.9825), PMMA vs. 5% PMMA （p=0.222）。然而，亚组分析表明，与纳米纤维增强PMMA相比，常规PMMA的抗弯强度更高，特别是在纳米纤维浓度较高的情况下(p结论：将纳米纤维掺入PMMA并没有显著提高抗弯强度，对其他物理力学性能的影响并不一致。因此，需要进一步规范的实验室和临床研究，以明确其疗效和临床适用性。
期刊介绍：
The Journal of Applied Oral Science is committed in publishing the scientific and technologic advances achieved by the dental community, according to the quality indicators and peer reviewed material, with the objective of assuring its acceptability at the local, regional, national and international levels. The primary goal of The Journal of Applied Oral Science is to publish the outcomes of original investigations as well as invited case reports and invited reviews in the field of Dentistry and related areas.
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