{"title":"Recent Advances on Diol Bioproduction.","authors":"Xueying Wang, Xiaohui Wu, Yongjin J Zhou","doi":"10.1007/10_2026_336","DOIUrl":null,"url":null,"abstract":"<p><p>Diols represent a vital class of bulk chemicals widely used in polymer materials, fine chemicals, cosmetics, and biomedical fields. Due to the advantages of renewable feedstock, mild reaction conditions, and stereoselectivity, biomanufacturing for diol production has attracted extensive attention. Although biosynthetic pathways for some diols exist in nature, utilizing native microorganisms for diol production faces challenges such as low product titer, limited product diversity, and poor strain tolerance, which fail to meet industrial requirements. This review summarizes both natural and nonnatural biosynthetic pathways of diols, with a focus on recently developed artificial routes. It further highlights advances made by Chinese researchers in strain development, systems metabolic engineering, and fermentation process optimization. Finally, this review discusses major challenges and future directions for diol biomanufacturing, offering significant insights for green and sustainable industrial-scale production.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in biochemical engineering/biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/10_2026_336","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Diols represent a vital class of bulk chemicals widely used in polymer materials, fine chemicals, cosmetics, and biomedical fields. Due to the advantages of renewable feedstock, mild reaction conditions, and stereoselectivity, biomanufacturing for diol production has attracted extensive attention. Although biosynthetic pathways for some diols exist in nature, utilizing native microorganisms for diol production faces challenges such as low product titer, limited product diversity, and poor strain tolerance, which fail to meet industrial requirements. This review summarizes both natural and nonnatural biosynthetic pathways of diols, with a focus on recently developed artificial routes. It further highlights advances made by Chinese researchers in strain development, systems metabolic engineering, and fermentation process optimization. Finally, this review discusses major challenges and future directions for diol biomanufacturing, offering significant insights for green and sustainable industrial-scale production.
期刊介绍：
Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 3 - 5 years. It also discusses new discoveries and applications.
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