Statin Use and the Risk of Proliferative Vitreoretinopathy in Eyes Undergoing Rhegmatogenous Retinal Detachment Repair.

IF 1.1 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2026-08-01 Epub Date: 2026-07-29 DOI:10.3928/23258160-20260618-01

Sidra Zafar, Nitika Aggarwal, Sudheshna Vemula, Turner Wibbelsman, Josee Winsor, Nick Boucher, Ajay E Kuriyan, Yoshihiro Yonekawa

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引用次数: 0

Abstract

Background and objective: This study aimed to evaluate the association between statin use and frequency of proliferative vitreoretinopathy (PVR) and return to the operating room in eyes undergoing rhegmatogenous retinal detachment (RRD) repair.

Patients and methods: This was a retrospective study of all patients ≥18 years of age who underwent RRD repair between January 2015 and November 2024, identified in the Vestrum Health Retina Database.

Results: A total of 54,876 eyes were included in the final analysis, of which 17,922 (33%) were taking statins. The frequency of PVR development within 90 days following primary RRD repair was significantly lower in the statin group compared to the non-statin group (6.67% vs. 8.17%, P < .001). In a multivariate regression analysis adjusted for age, sex, smoking history, lens status, diabetes, and surgery type, statin use was independently associated with a decreased likelihood of PVR (odds ratio: 0.70, 95% CI: 0.66 to 0.75).

Conclusion: Statin use was associated with a significantly lower risk for PVR formation and return to the operating room following primary RRD repair.

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他汀类药物的使用和孔源性视网膜脱离修复的眼部增生性玻璃体视网膜病变的风险。

背景与目的：本研究旨在评估他汀类药物的使用与孔源性视网膜脱离（RRD）修复术后增殖性玻璃体视网膜病变（PVR）和返回手术室的频率之间的关系。患者和方法：这是一项回顾性研究，在2015年1月至2024年11月期间，在Vestrum健康视网膜数据库中识别的所有≥18岁接受RRD修复的患者。结果：最终纳入54,876只眼，其中服用他汀类药物17,922只（33%）。与非他汀类药物组相比，他汀类药物组在原发性RRD修复后90天内PVR发生的频率显著降低（6.67% vs. 8.17%, P < 0.001）。在调整了年龄、性别、吸烟史、晶状体状态、糖尿病和手术类型的多因素回归分析中，他汀类药物的使用与PVR的可能性降低独立相关（优势比：0.70,95% CI: 0.66 ~ 0.75）。结论：他汀类药物的使用与原发性RRD修复后PVR形成和返回手术室的风险显著降低相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.