A retrospective cohort study of surgery for adrenocortical carcinoma in a tertiary endocrine surgery unit.

IF 2 4区医学 Q3 SURGERY

Annals of the Royal College of Surgeons of England Pub Date : 2026-08-06 DOI:10.1308/rcsann.2026.0079

N Kamalakkannan, F Tahir, S O'Toole, A Al-Mukhtar, J Newell-Price, S P Balasubramanian

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引用次数: 0

Abstract

Introduction: Adrenocortical cancer (ACC) is a rare endocrine malignancy with a variable prognosis. This study examines clinical outcomes of patients with ACC who underwent surgery in an endocrine surgery unit over 14 years.

Methods: Demographic, clinical, pathological and follow-up data on consecutive patients who underwent surgery for ACC or cortical tumours of uncertain malignant potential (UMP) and patients who had a clinical diagnosis of ACC were collected and descriptive analyses were conducted.

Results: Of 48 patients, 32 had ACC confirmed on histology, 10 had a clinical diagnosis and 6 had UMPs. Of those with a histological diagnosis, there were 12 men and 20 women with a median (range) age at first operation of 53 (16-77) years. The histologic type was oncocytic in eight (25%) patients and metastatic disease was present in six (19%) patients at time of operation. ENSAT staging was stage I in 2 (6%), stage II in 18 (56%), stage III in 5 (16%), stage IV in 6 (19%) and unknown in 1 (3%) patient. Complete resection was achieved in 16 (50%) patients. Adjuvant treatments included mitotane and external beam radiotherapy in 18 (56%) and 2 (6%) patients, respectively. Four patients (with initial surgery outside this centre) had multiple operations. The median (range) overall survival and median (range) time to persistent or recurrent disease was 33 (7-172) months and 8 (0-71) months in histology-proven ACC.

Conclusions: This study provides a contemporary perspective on epidemiology and practice in the management of ACC in the UK.

查看原文本刊更多论文

三级内分泌外科单位肾上腺皮质癌手术的回顾性队列研究。

简介：肾上腺皮质癌（ACC）是一种罕见的内分泌恶性肿瘤，预后多变。本研究调查了14年来在内分泌外科单位接受手术的ACC患者的临床结果。方法：收集连续行ACC或不确定恶性潜能皮质肿瘤（UMP）手术患者及临床诊断为ACC患者的人口学、临床、病理及随访资料，并进行描述性分析。结果：48例患者中，组织学确诊ACC 32例，临床诊断10例，UMPs 6例。在组织学诊断的患者中，有12名男性和20名女性，首次手术时的中位年龄（范围）为53岁（16-77岁）。8例（25%）患者的组织学类型为嗜瘤细胞性，6例（19%）患者在手术时存在转移性疾病。ENSAT分期为2例I期（6%），18例II期（56%），5例III期（16%），6例IV期（19%），1例未知（3%）。16例（50%）患者完全切除。辅助治疗包括米托坦和外束放疗，分别有18例（56%）和2例（6%）患者。四名患者（在该中心外进行了首次手术）进行了多次手术。组织学证实的ACC患者的中位总生存期（范围）和持续或复发疾病的中位时间（范围）分别为33（7-172）个月和8（0-71）个月。结论：本研究为英国ACC的流行病学和管理实践提供了当代视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of the Royal College of Surgeons of England Medicine-Surgery

CiteScore

2.40

自引率

0.00%

发文量

316

期刊介绍： The Annals of The Royal College of Surgeons of England is the official scholarly research journal of the Royal College of Surgeons and is published eight times a year in January, February, March, April, May, July, September and November. The main aim of the journal is to publish high-quality, peer-reviewed papers that relate to all branches of surgery. The Annals also includes letters and comments, a regular technical section, controversial topics, CORESS feedback and book reviews. The editorial board is composed of experts from all the surgical specialties.