Pharmacological Modulation of Nrf2 Signaling Regulates Oxidative Stress, Inflammation, and Alveolar Bone Loss in Experimental Periodontitis.

IF 5.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2026-08-05 DOI:10.1111/jre.70158

Vitória Bonan Costa, Mariely Araújo de Godoi, Angelo Constantino Camilli, Isabela Rinaldi Gomes Nogueira, Veronica Canela Estevam Dos Santos, Lucas Nogueira Ramos, Juliana Silva Siqueira, Camila Renata Corrêa Camacho, Morgana Rodrigues Guimarães Stabili

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引用次数: 0

Abstract

Aim: To investigate whether pharmacological modulation of Nrf2 signaling influences oxidative stress, inflammatory responses, and periodontal tissue destruction in experimental ligature-induced periodontitis.

Methods: Ligature-induced experimental periodontitis was established in rats treated with dimethyl fumarate (DMF), an Nrf2 activator, and/or ML385, a selective Nrf2 inhibitor. Alveolar bone loss, oxidative stress markers, inflammatory mediators, and histopathological changes were evaluated.

Results: Nrf2 activation attenuated alveolar bone loss, reduced oxidative stress, and decreased inflammatory mediators, accompanied by improved periodontal tissue organization. In contrast, Nrf2 inhibition exacerbated inflammation and increased periodontal tissue destruction.

Conclusion: Nrf2 signaling plays a regulatory role in periodontal inflammation and tissue breakdown. Pharmacological activation of Nrf2 exerts protective effects, whereas its inhibition aggravates disease severity.

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Nrf2信号在实验性牙周炎中调控氧化应激、炎症和牙槽骨丢失的药理作用

目的：探讨Nrf2信号的药理调节是否影响实验性结扎性牙周炎的氧化应激、炎症反应和牙周组织破坏。方法：用富马酸二甲酯（DMF）（Nrf2激活剂）和/或ML385 （Nrf2选择性抑制剂）治疗大鼠，建立结扎诱导的实验性牙周炎。评估牙槽骨丢失、氧化应激标志物、炎症介质和组织病理学变化。结果：Nrf2激活减轻了牙槽骨丢失，减少了氧化应激，减少了炎症介质，并改善了牙周组织组织。相反，Nrf2抑制会加重炎症，增加牙周组织破坏。结论：Nrf2信号在牙周炎症和组织破坏中起调节作用。Nrf2的药理激活具有保护作用，而其抑制会加重疾病的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.