{"title":"Platelet-Rich Plasma as Long-Term Therapy for Refractory Pain in an Atypical Case of Morton's Neuroma: A Case Report.","authors":"Muhamad Rafigi Hehsan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Morton's neuroma is a painful entrapment neuropathy typically affecting the third intermetatarsal space. Conventional therapies, including orthotics, corticosteroids, or surgery, often yield inconsistent outcomes.</p><p><strong>Case report: </strong>We describe a 26-year-old woman with chronic, persistent neuropathic pain due to an atypical Morton's neuroma located in the fourth intermetatarsal space. After failure of multiple conservative and infiltrative treatments, she received 2 injections of leukocyte-poor platelet-rich plasma (PRP). Pain severity (Visual Analog Scale) improved from 9/10 to 1/10, and the Foot Function Index improved by 75% at 12 months.</p><p><strong>Conclusions: </strong>PRP provided durable analgesia and functional recovery in this rare neuroma presentation, underscoring its regenerative and neuromodulatory potential. Our case highlights the effectiveness of PRP as a promising, minimally invasive alternative when conventional treatments fail.</p>","PeriodicalId":520525,"journal":{"name":"Pain medicine case reports","volume":"10 5","pages":"405-408"},"PeriodicalIF":0.0000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain medicine case reports","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Morton's neuroma is a painful entrapment neuropathy typically affecting the third intermetatarsal space. Conventional therapies, including orthotics, corticosteroids, or surgery, often yield inconsistent outcomes.
Case report: We describe a 26-year-old woman with chronic, persistent neuropathic pain due to an atypical Morton's neuroma located in the fourth intermetatarsal space. After failure of multiple conservative and infiltrative treatments, she received 2 injections of leukocyte-poor platelet-rich plasma (PRP). Pain severity (Visual Analog Scale) improved from 9/10 to 1/10, and the Foot Function Index improved by 75% at 12 months.
Conclusions: PRP provided durable analgesia and functional recovery in this rare neuroma presentation, underscoring its regenerative and neuromodulatory potential. Our case highlights the effectiveness of PRP as a promising, minimally invasive alternative when conventional treatments fail.
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