Copper dependency in leukemia metabolism

IF 28 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2026-08-03 DOI:10.1038/s43018-026-01205-3

Sarada Achyutuni, Jian Xu

引用次数: 0

Abstract

Despite their crucial roles in physiology, the contributions of trace metals to cancer fitness and therapy response remain unclear. Combining a CRISPR screen with functional and metabolic studies, recent work identifies copper homeostasis as a key regulator of mitochondrial metabolism and liability in cerebrospinal fluid-infiltrating acute lymphoblastic leukemia cells.

查看原文本刊更多论文

白血病代谢中的铜依赖。

尽管微量金属在生理上起着至关重要的作用，但它们对癌症适应性和治疗反应的贡献尚不清楚。将CRISPR筛选与功能和代谢研究相结合，最近的研究发现，在脑脊液浸润性急性淋巴细胞白血病细胞中，铜稳态是线粒体代谢和倾向的关键调节因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.