Effects of Different Living Environments on Intestinal Flora in Patients With Schistosoma Japonicum-Induced Liver Fibrosis

IF 3.6 3区生物学 Q2 MICROBIOLOGY

MicrobiologyOpen Pub Date : 2026-08-04 DOI:10.1002/mbo3.70366

Xiaofei Fan, Chen Zhou, Pengpeng Zhang, Yingzi Ming

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Abstract

Schistosomiasis japonica is a parasitic disease leading to liver cirrhosis. China's “fishermen going ashore” policy divides patients with schistosomiasis liver fibrosis into two groups: those near the infected waters and those inland far from the infected water. This study aims to compare the differences in intestinal flora between two groups from the perspective of intestinal flora, and provide a basis for future prevention and control priorities. This study collected feces and basic information of patients with Schistosoma japonicum cirrhosis living near infected water and living on land. The characteristics of intestinal flora of the two types of patients were compared by 16sRNA sequencing technology. The infected water contact group and the terrestrial living group showed significant differences in intestinal flora characteristics: the former showed dominance of Firmicutes, high α-diversity, enrichment of butyrate-producing bacteria (such as Blautia), and enhanced environmental adaptability; the latter showed an imbalanced state with increased Proteobacteria and reduced α-diversity, accompanied by abnormal lipid metabolism and barrier function damage.

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不同生活环境对日本血吸虫肝纤维化患者肠道菌群的影响

日本血吸虫病是一种导致肝硬化的寄生虫病。中国的“渔民上岸”政策将血吸虫病肝纤维化患者分为两组：靠近受感染水域的患者和远离受感染水域的患者。本研究旨在从肠道菌群的角度比较两组肠道菌群的差异，为今后的防治重点提供依据。本研究收集了日本血吸虫肝硬化患者的粪便和基本信息，这些患者生活在受感染的水域附近和生活在陆地上。采用16sRNA测序技术比较两类患者肠道菌群特征。感染水接触组与陆生组肠道菌群特征差异显著：前者以厚壁菌门为主，α-多样性高，丁酸产菌（如Blautia）富集，环境适应性增强；后者呈现不平衡状态，变形菌群增加，α-多样性降低，脂质代谢异常，屏障功能受损。

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来源期刊

MicrobiologyOpen MICROBIOLOGY-

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

20 weeks

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