Non-invasive serum markers at admission in patients with spontaneous bacterial peritonitis.

IF 1.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI:10.24875/GMM.M26001075

Raúl A Jiménez-Castillo, Luis A González-Torres, Oveed Olloqui-Martínez, José M Yáñez-Reyes, José A González-González, Joel O Jáquez-Quintana, Héctor J Maldonado-Garza, Gabriela E Aguilar-Díaz, Homero Náñez-Terreros, Carlos A Cortez-Hernández

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引用次数: 0

Abstract

Background: Patients with liver cirrhosis are prone to bacterial infections, particularly spontaneous bacterial peritonitis (SBP). Previous studies evaluating the usefulness of non-invasive markers in predicting survival in SBP patients have yielded heterogeneous results.

Objective: To assess the utility of the neutrophil-to-lymphocyte ratio (NLR), MELD-Na score, and serum lactate as non-invasive markers for predicting 28-day survival in patients with SBP.

Materials and methods: This study employed a descriptive and retrospective design. The optimal cut-off values for MELD-Na, serum lactate, and NLR to predict 28-day mortality and survival were determined using ROC curves. We analyzed the relation of these markers to the presence of acute kidney injury.

Results: We included 74 patients with a first episode of SBP. The median age was 55 years. The optimal NLR cut-off to predict mortality was ≥ 9.68, MELD-Na ≥ 27.5, and serum lactate ≥ 3.35. For predicting acute kidney injury, the optimal values were NLR ≥ 9.2 and MELD-Na ≥ 25.

Conclusions: MELD-Na, NLR, and serum lactate are easily accessible serum markers that may support the prediction of short-term survival.

查看原文本刊更多论文

自发性细菌性腹膜炎患者入院时的无创血清标志物。

背景：肝硬化患者易发生细菌感染，尤其是自发性细菌性腹膜炎（SBP）。先前评估非侵入性标志物在预测收缩压患者生存中的有效性的研究得出了不同的结果。目的：评估中性粒细胞与淋巴细胞比值（NLR）、MELD-Na评分和血清乳酸作为预测收缩压患者28天生存率的非侵入性指标的效用。材料和方法：本研究采用描述性和回顾性设计。使用ROC曲线确定MELD-Na、血清乳酸和NLR预测28天死亡率和生存率的最佳临界值。我们分析了这些标志物与急性肾损伤的关系。结果：我们纳入了74例首次收缩压发作的患者。中位年龄为55岁。预测死亡率的最佳NLR截止值≥9.68,MELD-Na≥27.5，血清乳酸≥3.35。预测急性肾损伤的最佳值为NLR≥9.2,MELD-Na≥25。结论：MELD-Na、NLR和血清乳酸是容易获得的血清标志物，可能支持预测短期生存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gaceta medica de Mexico 医学-医学：内科

CiteScore

1.00

自引率

0.00%

发文量

216

审稿时长

6-12 weeks

期刊介绍： Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice. Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.