Role of Tonsillectomy in Cervical Squamous Cell Carcinoma With Unknown Primary in Human Papillomavirus-Negative Patients: A Prospective Observational Study.

IF 2.1 4区医学 Q4 ONCOLOGY

Asia-Pacific journal of clinical oncology Pub Date : 2026-08-03 DOI:10.1111/ajco.70150

Prateek V Jain, Bibek Khanal, Vikram Kekatpure, Kapila Manikantan, Gurucharan Sahu, Sanjoy Chatterjee, Indranil Mallick, Pattatheyil Arun

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引用次数: 0

Abstract

Introduction: Management of cervical squamous cell carcinoma with unknown primary (SCCUP) continues to evolve with emphasis on tonsillectomy for identification of the primary. While the data from an HPV positive population is compelling, surgical ablation of potential primary sites in the oropharynx with the goal of identifying the primary in HPV negative tumors is debated.

Methods: In this prospective observational study, 21 patients with SCCUP underwent bilateral tonsillectomy in an attempt to identify a possible site of primary.

Results: Median age of this cohort was 59 years (39-74 years). Two of twenty patients were p16 positive. Only 1 patient (p16 positive) revealed a primary in the tonsil. Fifteen patients received adjuvant concurrent chemoradiation (CTRT), whereas two patients received adjuvant radiotherapy (RT). Median follow up was 17.6 months (0.26-60 months). The 2-year overall and disease-free survival rates were 81.5% (52.6%-93.7%) and 70.1% (42.1%-86.4%), respectively. No patient evinced mucosal recurrence.

Conclusions: Prevalence of human papilloma virus in patients with SCCUP is very low in India. Role of bilateral tonsillectomy to identify primary lesion in p16 negative patients is questionable.

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扁桃体切除术在人乳头瘤病毒阴性患者原发不明的宫颈鳞状细胞癌中的作用：一项前瞻性观察研究

简介：原发不明的宫颈鳞状细胞癌（SCCUP）的治疗方法不断发展，重点是扁桃体切除术以确定原发。虽然来自HPV阳性人群的数据是令人信服的，但以确定HPV阴性肿瘤的原发肿瘤为目标，对口咽部潜在原发部位进行手术消融仍存在争议。方法：在这项前瞻性观察研究中，21例SCCUP患者接受了双侧扁桃体切除术，试图确定可能的原发部位。结果：该队列的中位年龄为59岁（39-74岁）。20例患者中2例p16阳性。只有1例患者（p16阳性）在扁桃体中发现原发灶。15例患者接受辅助同步放化疗（CTRT）， 2例患者接受辅助放疗（RT）。中位随访时间为17.6个月（0.26 ~ 60个月）。2年总生存率为81.5%(52.6% ~ 93.7%)，无病生存率为70.1%（42.1% ~ 86.4%）。未见粘膜复发。结论：人乳头瘤病毒在印度SCCUP患者中的流行率很低。双侧扁桃体切除术在p16阴性患者中识别原发病变的作用值得怀疑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia-Pacific journal of clinical oncology 医学-肿瘤学

CiteScore

3.40

自引率

0.00%

发文量

175

审稿时长

6-12 weeks

期刊介绍： Asia–Pacific Journal of Clinical Oncology is a multidisciplinary journal of oncology that aims to be a forum for facilitating collaboration and exchanging information on what is happening in different countries of the Asia–Pacific region in relation to cancer treatment and care. The Journal is ideally positioned to receive publications that deal with diversity in cancer behavior, management and outcome related to ethnic, cultural, economic and other differences between populations. In addition to original articles, the Journal publishes reviews, editorials, letters to the Editor and short communications. Case reports are generally not considered for publication, only exceptional papers in which Editors find extraordinary oncological value may be considered for review. The Journal encourages clinical studies, particularly prospectively designed clinical trials.