Microfluidic Three-Dimensionally Printed Multicomponent Chinese Medicine Hydrogel Patches for Skin Photodamage Treatment

IF 8.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2026-08-03 Epub Date: 2026-07-01 DOI:10.1021/acsmaterialslett.6c00488

Xuan Wang, Xinyue Cao, Lingbao Zeng, Yuanjin Zhao

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引用次数: 0

Abstract

Traditional Chinese medicine exhibits considerable therapeutic potential in skin photodamage treatment. Current research focuses on improving its delivery system and therapeutic effect. Here, microfluidic 3D-printed multicomponent Chinese medicine Crocin (CR) and Dendrobium officinale polysaccharide (DOP) hybrid hydrogel patches are proposed for promoting photodamaged skin repair. By using the 3D printing technology, CR and DOP mixed hydrogels have been spun and knitted into microfiber patches. Benefiting from the good biocompatibility, porous structure, and high moisture retention, the hydrogels could provide an ideal microenvironment for cellular survival. Meanwhile, the loaded CR and DOP could be effectively released and synergistically exhibit antioxidant and antibacterial properties, thus scavenging the excessive reactive oxygen species (ROS) and reducing the bacterial infection risks at the photodamaged sites. We believe that the microfluidic 3D-printed multicomponent Chinese medicine hydrogel patches are promising effective dressings for future skin photodamage management and cosmeceutical development.

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微流控三维打印多组分中药水凝胶贴片治疗皮肤光损伤

中药在皮肤光损伤治疗中显示出相当大的治疗潜力。目前的研究重点是改善其给药系统和治疗效果。本研究提出了一种微流控3d打印的多组分中药藏红花素（CR）和铁皮石斛多糖（DOP）混合水凝胶贴剂，用于促进光损伤皮肤修复。利用3D打印技术，将CR和DOP混合水凝胶纺成超细纤维贴片。水凝胶具有良好的生物相容性、多孔结构和较高的保湿性，为细胞存活提供了理想的微环境。同时，负载的CR和DOP能够有效释放并协同表现出抗氧化和抗菌特性，从而清除光损伤部位过量的活性氧（ROS），降低细菌感染风险。我们相信，微流控3d打印的多组分中药水凝胶贴剂是未来皮肤光损伤管理和药妆开发的有效敷料。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.