Ultralow Noise Orthogonal Fluxgates Enabling Weak Magnetic Field and Biomolecular Detection

IF 36.3 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2026-08-03 DOI:10.1007/s40820-026-02317-2

Xiaofeng Pu, Zhijun Sheng, Zhoulu Yu, Huaidong Li, Xintao Wei, Tao Yang, Qingfang Liu, Guozhi Chai, Xiaolei Liang, Daqiang Gao

{"title":"Ultralow Noise Orthogonal Fluxgates Enabling Weak Magnetic Field and Biomolecular Detection","authors":"Xiaofeng Pu, Zhijun Sheng, Zhoulu Yu, Huaidong Li, Xintao Wei, Tao Yang, Qingfang Liu, Guozhi Chai, Xiaolei Liang, Daqiang Gao","doi":"10.1007/s40820-026-02317-2","DOIUrl":null,"url":null,"abstract":"<div><h2>Highlights</h2><div>\n \n <ul>\n <li>\n <p>A low-noise orthogonal fluxgate was developed using a CoP/Ag composite core with an amorphous-nanocrystalline dual-phase structure.</p>\n </li>\n <li>\n <p>The amorphous–nanocrystalline core is associated with reduced magnetic loss and improved domain regularity and, together with closed-loop feedback, enables a noise floor of 8 pT/√Hz at 1 Hz.</p>\n </li>\n <li>\n <p>The sensor enables Alpha-fetoprotein (AFP) immunomagnetic detection with a linear range of 50 fg mL<sup>−1</sup>–100 ng mL<sup>−1</sup> and a detection limit of 50 fg mL<sup>−1</sup>, demonstrating competitive sensitivity for AFP immunomagnetic detection.</p>\n </li>\n </ul>\n </div></div>","PeriodicalId":714,"journal":{"name":"Nano-Micro Letters","volume":"19 1","pages":""},"PeriodicalIF":36.3000,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433690/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Micro Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40820-026-02317-2","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}

引用次数: 0

Abstract

Highlights

A low-noise orthogonal fluxgate was developed using a CoP/Ag composite core with an amorphous-nanocrystalline dual-phase structure.
The amorphous–nanocrystalline core is associated with reduced magnetic loss and improved domain regularity and, together with closed-loop feedback, enables a noise floor of 8 pT/√Hz at 1 Hz.
The sensor enables Alpha-fetoprotein (AFP) immunomagnetic detection with a linear range of 50 fg mL⁻¹–100 ng mL⁻¹ and a detection limit of 50 fg mL⁻¹, demonstrating competitive sensitivity for AFP immunomagnetic detection.

查看原文本刊更多论文

实现弱磁场和生物分子检测的超低噪声正交磁通门。

超弱生物磁信号的无创检测对现代生物传感至关重要，但传统的磁传感器从根本上受到固有噪声的限制。正交磁通门（ofg）能够实现对弱磁场的高信噪比检测，但其性能仍然受到固有1/f噪声和巴克豪森相关磁波动的限制。本研究报告了一种低噪声正交磁通门，其中新设计的磁芯和电路减轻了现有的噪声限制。CoP/Ag复合磁芯具有非晶纳米双相结构，降低了低频磁损耗，提高了噪声性能。当与闭环反馈集成时，该传感器在1hz时的本底噪声为8 pT/√Hz。该传感器能够可靠地检测超低浓度磁珠信号。甲胎蛋白（AFP）被用作免疫磁珠测定中的模型生物标志物，产生从50 fg mL-1到100 ng mL-1的线性响应，检测限为50 fg mL-1，与代表性的AFP磁性生物传感器相比具有优势。OFGs在生物传感、地磁测量和弱场探测方面具有很强的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.