FeCl3/TBHP‐Mediated Mechanochemical Driven C–H Alkylation of Indolizines With Maleimides: Synthesis of 3‐(Indolizin‐3‐yl)Succinimides

IF 2.3 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI:10.1002/ajoc.70494

Pratiksha Jangir, Bhawani, Vani Dhyani, Krishnan Rangan, Anil Kumar

引用次数: 0

Abstract

A FeCl₃/TBHP‐promoted mechanochemical‐driven reaction of indolizines with maleimides that provides a rapid and sustainable method for the synthesis of 3‐(indolizin‐3‐yl)succinimides. The protocol offers several advantages over liquid‐phase synthesis and demonstrates a broad substrate scope, converting various indolizines and diverse maleimides into the corresponding 3‐(indolizin‐3‐yl)succinimides in up to 89% yield. The developed synthetic protocol features excellent functional group tolerance, operational simplicity, solvent‐free conditions, and high efficiency. Preliminary mechanistic studies unveiled that the reaction might be realized by a radical pathway.

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FeCl3/TBHP介导的机械化学驱动吲哚嗪与马来酰亚胺的C-H烷基化反应：3 -（吲哚嗪- 3 -酰基）琥珀酰亚胺的合成

FeCl3/TBHP促进了吲哚嗪与马来酰亚胺的机械化学驱动反应，为3 -（吲哚嗪- 3 -酰基）琥珀酰亚胺的快速合成提供了一种可持续的方法。与液相合成相比，该方法具有许多优点，并且具有广泛的底物范围，可将各种吲哚嗪和马来酰亚胺转化为相应的3 -（吲哚嗪- 3 -酰基）琥珀酰亚胺，收率高达89%。开发的合成方案具有良好的官能团耐受性，操作简单，无溶剂条件和高效率。初步机理研究表明，该反应可能通过自由基途径实现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.