Modular Synthesis of N,N’‐Disubstituted Triazolyl Ureas via a Transition‐Metal‐Free KOtBu‐Promoted Three‐Component Reaction

IF 2.3 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-07-01 Epub Date: 2026-08-04 DOI:10.1002/ajoc.70499

Weiguo Wang, Chunpeng Qiu, Zhihao Zuo, Jingyu Wang

引用次数: 0

Abstract

Herein, a transition‐metal‐free KO^tBu‐promoted three‐component reaction has been developed for the modular synthesis of N,N’‐disubstituted triazolyl ureas. This reaction proceeded via the cycloaddition of nitriles and azides in the presence of a base, followed by the interception of the triazolamine and triazole nitrogen anion intermediate using isocyanates. This reaction operates under mild reaction conditions and features in a broad substrate scope.

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通过无过渡金属KOtBu促进的三组分反应模块化合成N，N ' -二取代三唑脲

本文提出了一种无过渡金属KOtBu促进的三组分反应，用于N，N ' -二取代三唑脲的模块化合成。这个反应是通过在碱的存在下将腈和叠氮化物环加成，然后用异氰酸酯截取三唑胺和三唑氮阴离子中间体进行的。该反应在温和的反应条件下进行，其特点是底物范围广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.