Bioelectric Phase Angle and Appendicular Skeletal Muscle Mass in Rheumatoid Arthritis: Association With Disease Activity, Impact of Disease, and Functional Disability.
Sofia Charneca, Catarina Costa, João Vasques, Margarida Ferro, Elisabete Carolino, Joana Martins-Martinho, Ana Margarida Duarte-Monteiro, Eduardo Dourado, Joaquim Polido-Pereira, João Eurico Fonseca, Catarina Sousa Guerreiro
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引用次数: 0
Abstract
Objective: Adverse changes in body composition are increasingly being recognized in patients with rheumatoid arthritis (RA). This study aimed to explore the relationship between RA disease activity, disease impact, and functional disability with bioelectrical phase angle (PhA) and appendicular skeletal muscle mass index (ASMI).
Methods: Patients with RA were recruited at a tertiary hospital in Portugal. The Disease Activity Score in 28 joints based on erythrocyte sedimentation rate and C-reactive protein (DAS28-ESR and DAS28-CRP, respectively) were used to assess disease activity. The impact of disease and functional status were evaluated using the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire and the Health Assessment Questionnaire (HAQ), respectively. Body composition was measured by bioelectrical impedance analysis (BIA). PhA was stratified into tertiles, and ASMI was classified according to the European Working Group on Sarcopenia in Older People 2 criteria.
Results: A total of 104 patients with RA were included (74% female; mean age 60.9 [SD 9.6] years). RAID scores were significantly lower in patients in the highest PhA tertile (PhA-T3) than in those in the lower PhA tertiles (PhA-T2 and PhA-T1, P = 0.001 and P < 0.001, respectively). HAQ scores were significantly lower in patients in the highest PhA tertile (PhA-T3) than in those in the lowest PhA tertile (PhA-T1, P < 0.001). Median DAS28-ESR and DAS28-CRP were lower among patients with higher PhA, but the difference did not reach statistical significance (P = 0.07 and P = 0.16, respectively). No differences were found among the ASMI groups in DAS28-ESR (P = 0.62), DAS28-CRP (P = 0.97), RAID (P = 0.30), or HAQ (P = 0.51) scores.
Conclusion: A lower PhA was associated with greater disease impact and greater significant functional disability in patients with RA.
期刊介绍：
The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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