Dietary and Endogenous Advanced Glycation End Product and Breast Carcinogenesis: A Challenging Lack of Association in a Rigorous Case-Control Study.

IF 4 Q3 NUTRITION & DIETETICS

Journal of Nutrition and Metabolism Pub Date : 2026-07-31 eCollection Date: 2026-01-01 DOI:10.1155/jnme/6687630

Sadaf Alipour, Ramesh Omranipour, Alireza Abdollahi, Behnaz Jahanbin, Bardia Gholami, Sakineh Shab-Bidar, Amirnader Emami-Razavi, Maryam Selk-Ghaffari, Foroozan Ghalkhani, Azin Saberi, Zahra Morovati, Marzieh Orouji, Maryam Haghighi, Mahtab Vasigh, Elham Nazar, Samareh Heydari, Sareh Saien, Bita Eslami

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引用次数: 0

Abstract

Introduction: Advanced Glycation End (AGE) Product is produced by atypical metabolism when food is cooked at high temperatures in a short time, such as roasted foods, or when chemicals are added as in processed foods. Research on the association between AGE and breast cancer (BC) has been inconclusive.

Methods: This multicenter case-control study investigated the relationship between serum AGE (sAGE), tissue AGE (tAGE), and dietary AGE (dAGE) and BC, considering physical activity (PA). The study included 44 hormone receptor-positive premenopausal BC patients and 42 controls. Data on diet and PA were collected using validated Persian questionnaires. sAGE and tAGE were measured using blood and tissue samples.

Results: The dAGE was 16,104.98 ± 6542.04 and 15,084.53 ± 5827.69 kilo-units/day, while PA was significantly lower in cases than controls (773.64 ± 829.92 vs. 1920.95 ± 2999.91 MET-minutes/week, p = 0.02). The mean sAGE was 626.11 ± 695.00 ng/mL in cases and 713.93 ± 829.67 in controls. tAGE was positive in 34.1% and 28.6% of cases and controls.

Conclusion: We found no association between dAGE and BC or dAGE and sAGE or tAGE. PA was less in the BC group but unrelated to sAGE and dAGE. As we accounted for all relevant variables, our negative findings provide strong evidence against an association between AGEs in diet, PA, and BC.

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饮食和内源性晚期糖基化终产物与乳腺癌的发生：在一项严格的病例对照研究中缺乏挑战性的关联。

高级糖基化终产物（AGE）是在高温短时间内烹饪食物时，如烘烤食品，或在加工食品中添加化学物质时，由非典型代谢产生的产物。关于AGE与乳腺癌（BC）之间关系的研究尚无定论。方法：本多中心病例对照研究考察血清AGE （sAGE）、组织AGE （tAGE）和膳食AGE （dAGE）与BC之间的关系，并考虑体力活动（PA）。该研究包括44名激素受体阳性的绝经前BC患者和42名对照组。饮食和前列腺癌的数据通过波斯语问卷收集。使用血液和组织样本测量sAGE和tAGE。结果：患者的age分别为16,104.98±6542.04和15,084.53±5827.69 kg -units/day， PA明显低于对照组（773.64±829.92 vs 1920.95±2999.91 MET-minutes/week, p = 0.02）。平均sAGE为626.11±695.00 ng/mL，对照组为713.93±829.67 ng/mL。病例和对照组中age阳性率分别为34.1%和28.6%。结论：我们没有发现dAGE与BC或dAGE与sAGE或age之间的关联。BC组PA较少，但与sAGE和age无关。由于我们考虑了所有相关变量，我们的阴性结果提供了强有力的证据，反对饮食中AGEs、PA和BC之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition and Metabolism NUTRITION & DIETETICS-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.