Rebecca J Egbert, John P Buchweitz, Madison A Godfrey, Brian K Petroff
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引用次数: 0
Abstract
Objective: To characterize the total and inorganic serum iodine concentrations of canines with varying thyroid disease status.
Methods: Leftover serum samples submitted to the Michigan State University Veterinary Diagnostic Laboratory for diagnostic thyroid panel screening between January and June 2023 were utilized for this retrospective study. Thyroglobulin autoantibody was used as a marker for autoimmune thyroiditis. Inorganic and total iodine were measured via an inductively coupled plasma-mass spectrometer. An estimated reference interval was calculated for inorganic and total iodine using results from euthyroid dogs.
Results: Iodine concentrations were measured in dogs with autoimmune thyroiditis (n = 101) and hypothyroidism (97) and euthyroid dogs (86). Serum iodine concentrations ranged widely but were not increased in dogs with autoimmune thyroiditis or hypothyroidism in comparison to euthyroid animals. Concentrations of both total and inorganic iodine were statistically different between dogs suffering from autoimmune thyroiditis and those with hypothyroidism.
Conclusions: Elevated serum iodine is not associated with autoimmune thyroiditis or hypothyroidism in dogs.
Clinical relevance: The concentration of iodine alone in canine serum is not a marker for thyroid disease in dogs.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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