Development of remineralizing dental composites incorporating prepolymerized particles charged with CaF₂.

IF 6.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2026-08-01 DOI:10.1016/j.dental.2026.07.024

Mariana Araújo Barros, Renata Nunes Jardim, Milena Alves Crespo Azevedo, Anderson Araújo Rocha, Dalber Ruben Sanchez Candela, Aline de Almeida Neves, Maristela Barbosa Portela, Eduardo Moreira da Silva

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引用次数: 0

Abstract

Objectives: To develop remineralizing dental composites incorporating prepolymerized TMPTMA-HEMA particles charged with CaF₂ (THCaF₂).

Methods: Blends of TMPTMA-HEMA (50/50 wt%), charged with CaF₂ (5, 10, and 15 wt%), were heat-polymerized and crushed to a micrometric scale (THCaF₂). Four dental composites were produced using the same organic matrix (30 wt%) of Bis-GMA/TEGDMA (70/30 wt%). The control composite (C) contained 70 wt% barium borosilicate (BaBSi) fillers, whereas, in CaF5, CaF10, and CaF15, BaBSi fillers were partially replaced by 20 wt% of THCaF₂ particles. The remineralizing potential was evaluated through F⁻ release and the remineralization of caries-like enamel lesions induced by S. mutans biofilm using micro-CT. Physicomechanical properties included degree of conversion (DC%), flexural strength (FS), flexural modulus (FM), water sorption (Wsp), and water solubility (Wsl). Data were analyzed using one-way ANOVA and Tukey's HSD test (α = 0.05).

Results: All composites containing THCaF₂ released F⁻ ions, whereas only CaF10 and CaF15 induced enamel remineralization. The DC% did not differ among the dental composites (p > 0.05). C showed the highest FS and FM (p < 0.05), whereas the FS and FM of the other composites did not differ from one another (p > 0.05). The lowest Wsp was observed for C (p < 0.05), followed by CaF5, CaF10, and CaF15, which did not differ statistically from one another (p > 0.05). No statistical difference in Wsl was found among the dental composites (p > 0.05).

Significance: The incorporation of prepolymerized particles charged with CaF₂ (THCaF₂) conferred remineralizing potential to experimental dental composites and represents a promising strategy for developing dental composites capable of preventing enamel demineralization caused by the caries process.

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含带CaF2的预聚合颗粒的再矿化牙科复合材料的研制。

目的：研制含带CaF 2 （THCaF 2）的预聚合TMPTMA-HEMA颗粒的再矿化牙科复合材料。方法：TMPTMA-HEMA（50/50 wt%）共混物，充入CaF 2(5、10和15 wt%)，热聚合并粉碎至微米级（THCaF 2）。使用Bis-GMA/TEGDMA（70/30 wt%）的相同有机基质（30 wt%）制备四种牙科复合材料。对照复合材料(C)含有70 wt%的硼硅酸钡（BaBSi）填料，而在CaF5、CaF10和CaF15中，BaBSi填料部分被20 wt%的thcaf2颗粒所取代。通过F -释放和变形链球菌生物膜对龋样牙釉质损伤的再矿化作用，利用micro-CT评价再矿化电位。物理力学性能包括转化率（DC%）、抗弯强度（FS）、抗弯模量（FM）、吸水性（Wsp）和水溶性（Wsl）。数据分析采用单因素方差分析和Tukey’s HSD检验（α = 0.05）。结果：含thcaf2的复合材料均释放F -毒血症，而只有CaF10和CaF15引起牙釉质再矿化。不同牙体复合材料的DC%差异无统计学意义（p > 0.05）。C组FS和FM最高（p  0.05）。C的Wsp最低（p  0.05）。口腔复合材料的Wsl差异无统计学意义（p > 0.05）。意义：带CaF - 2 （THCaF - 2）的预聚合颗粒的掺入为实验性牙科复合材料提供了再矿化潜力，代表了开发能够防止龋病过程引起的牙釉质脱矿的牙科复合材料的有前途的策略。

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.