S. A. Meshcheryakova, V. V. Olomskaya, D. D. Drozd, O. A. Goryacheva, I. Yu. Goryacheva
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引用次数: 0
Abstract
A procedure for determining doxorubicin in the presence of bortezomib in model aqueous solutions and blood plasma is developed based on the fluorescence quenching of CdZnSeS/ZnS and AgInS/ZnS quantum dots. Since doxorubicin is often used in combination chemotherapy with bortezomib, monitoring its plasma concentration is important for increasing the effectiveness of chemotherapy and reducing the risk of side effects. The sensitivity of doxorubicin determination in the presence of bortezomib (0.3 μM) is compared using quantum dots with different surface ligands. A trend toward decreased fluorescence quenching efficiency of quantum dots by doxorubicin in the presence of bortezomib is demonstrated. The use of alloyed CdZnSeS/ZnS quantum dots stabilized with 3-mercaptropropionic acid for the determination of doxorubicin in the presence of bortezomib in plasma is demonstrated, with a detection limit of 0.08 μM and a quantification limit of 0.24 μM.
期刊介绍：
The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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