{"title":"Photoluminescence-Based DNA Biosensing of Tuberculosis Using Defect-Rich Cerium Oxide Nanomaterials","authors":"Jeba Grace Tigga, Manoj Kumar Patel","doi":"10.1021/acsaom.6c00198","DOIUrl":null,"url":null,"abstract":"<p>Defect-engineered cerium oxide (CeO<sub>2</sub>) nanosheets\r\nwere\r\ndeveloped as a label-free photoluminescence (PL) platform for ultrasensitive\r\nDNA detection. The CeO<sub>2</sub> nanosheets exhibited defect-mediated\r\nemission associated with oxygen vacancies. Probe DNA (ssDNA) immobilization\r\nenhanced PL intensity due to surface passivation, whereas hybridization\r\nwith complementary target DNA (tDNA) induced significant PL quenching\r\nvia guanine-mediated photoinduced electron transfer (PET). The biosensor\r\nshowed a linear detection range of 0.35 to 42 pM with a low detection\r\nlimit of 0.179 pM. Excellent selectivity and successful detection\r\nin clinical DNA samples demonstrate the potential of CeO<sub>2</sub> nanosheets for sensitive optical DNA biosensing.</p>","PeriodicalId":29803,"journal":{"name":"ACS Applied Optical Materials","volume":"4 7","pages":"1992–1999"},"PeriodicalIF":3.4000,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Optical Materials","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsaom.6c00198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Defect-engineered cerium oxide (CeO2) nanosheets
were
developed as a label-free photoluminescence (PL) platform for ultrasensitive
DNA detection. The CeO2 nanosheets exhibited defect-mediated
emission associated with oxygen vacancies. Probe DNA (ssDNA) immobilization
enhanced PL intensity due to surface passivation, whereas hybridization
with complementary target DNA (tDNA) induced significant PL quenching
via guanine-mediated photoinduced electron transfer (PET). The biosensor
showed a linear detection range of 0.35 to 42 pM with a low detection
limit of 0.179 pM. Excellent selectivity and successful detection
in clinical DNA samples demonstrate the potential of CeO2 nanosheets for sensitive optical DNA biosensing.
期刊介绍：
ACS Applied Optical Materials is an international and interdisciplinary forum to publish original experimental and theoretical including simulation and modeling research in optical materials complementing the ACS Applied Materials portfolio. With a focus on innovative applications ACS Applied Optical Materials also complements and expands the scope of existing ACS publications that focus on fundamental aspects of the interaction between light and matter in materials science including ACS Photonics Macromolecules Journal of Physical Chemistry C ACS Nano and Nano Letters.The scope of ACS Applied Optical Materials includes high quality research of an applied nature that integrates knowledge in materials science chemistry physics optical science and engineering.
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