Predicting hepatic perfusion and clearance in hepatocellular carcinoma patients using Gd-EOB-DTPA-enhanced MRI

IF 5.2 3区医学 Q1 SURGERY

Asian Journal of Surgery Pub Date : 2026-08-01 Epub Date: 2025-12-31 DOI:10.1016/j.asjsur.2025.12.066

Jinghui Feng, Xukun Zhang, Jinpeng Tan, Minghao Han, Dongxue Qi, Xiaoying Wang, Lihua Zhang

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引用次数: 0

Abstract

Objective

To assess the associations of Gd-EOB-DTPA-enhanced MRI features with hepatic perfusion and clearance in hepatocellular carcinoma (HCC) patients.

Methods

A total of 79 patients diagnosed with HCC, waiting for transcatheter arterial chemoembolization (TACE), were retrospectively enrolled in this study. They all received Gd-EOB-DTPA-enhanced MRI, ICG-R15, and other necessary tests. Liver images were obtained at 20 min after Gd-EOB-DTPA enhancement and radiomic features were extracted from these images using gray-level matrix. Relative liver enhancement (RLE), liver-to-spleen ratio (LSR), liver-to-muscle ratio (LMR) and reduction rate of T1 relaxation time of the liver (rrT1) were quantified and were estimated in left lobe and right lobe separately.

Results

Correlation analysis suggested that there were significant correlations between ICG-related traits and MRI features except the LSR of left lobe. Intriguingly, the LMR of left lobe displayed the largest correlation coefficient with ICG-K (R = 0.49, 95 % CI [0.30, 0.64]) while the rrT1rt displayed the largest coefficient with other ICG-related traits. The univariable and multivariable analyses implicated that rrT1rt should be the independent predictor of liver function compared with other parameters.

Conclusion

Gd-EOB-DTPA enhancement MRI can well reflect the liver function and the rrT1rt parameter displays the independent correlation and the best predictive performance.

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使用gd - eob - dtpa增强MRI预测肝细胞癌患者的肝脏灌注和清除

目的探讨gd - eob - dtpa增强MRI特征与肝细胞癌（HCC）患者肝脏灌注和清除的关系。方法回顾性分析79例HCC患者经导管动脉化疗栓塞（TACE）的临床资料。所有患者均接受gd - eob - dtpa增强MRI、ICG-R15及其他必要检查。Gd-EOB-DTPA增强后20min获得肝脏图像，并使用灰度矩阵提取图像的放射学特征。量化肝相对增强率（RLE）、肝脾比（LSR）、肝肌比（LMR）和肝T1弛豫时间减少率（rrT1），分别在左叶和右叶进行估计。结果相关分析显示，除左叶LSR外，icg相关特征与MRI特征均有显著相关。有趣的是，左叶LMR与ICG-K的相关系数最大（R = 0.49, 95% CI [0.30, 0.64]）， rrT1rt与其他icg相关性状的相关系数最大。单变量和多变量分析表明，与其他参数相比，rrT1rt应该是肝功能的独立预测因子。结论gd - eob - dtpa增强MRI能较好地反映肝功能，rrT1rt参数具有独立相关性，预测效果最佳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Surgery 医学-外科

CiteScore

3.60

自引率

31.40%

发文量

1589

审稿时长

33 days

期刊介绍： Asian Journal of Surgery, launched in 1978, is the official peer-reviewed open access journal of the Asian Surgical Association, the Taiwan Robotic Surgery Association, and the Taiwan Society of Coloproctology. The Journal is published monthly by Elsevier and is indexed in SCIE, Medline, ScienceDirect, Scopus, Embase, Current Contents, PubMed, Current Abstracts, BioEngineering Abstracts, SIIC Data Bases, CAB Abstracts, and CAB Health. ASJSUR has a growing reputation as an important medium for the dissemination of cutting-edge developments in surgery and its related disciplines in the Asia-Pacific region and beyond. Studies on state-of-the-art surgical innovations across the entire spectrum of clinical and experimental surgery are particularly welcome. The journal publishes original articles, review articles, and case reports that are of exceptional and unique importance. The journal publishes original articles, review articles, and case reports that are of exceptional and unique importance.